2012 Fiscal Year Final Research Report
Mechanisms underlying cell function of cardiac myocytes and pancreatic・cells by developing mathematical cell models
| Project/Area Number |
22390039
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
NOMA Akinori 立命館大学, 生命科学部, 教授 (00132738)
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| Co-Investigator(Renkei-kenkyūsha) |
CHA Chae young 立命館大学, 立命館グローバル・イノベーション研究機構, ポストドクトラルフェロ (20456867)
AMANO Akira 立命館大学, 生命科学部, 教授 (60252491)
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| Project Period (FY) |
2010 – 2012
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| Keywords | システム生理 / フィジオーム / 心筋 |
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| Research Abstract |
The mechanisms underlying the cell function were clarified by developing mathematical cell models based on scientific findings so far published in scientific literature. Thetime-dependent changes of cell functions, such as the electrical and mechanical functionsof cardiac myocyte and the glucose-dependent release of insulin release, werereconstructed by numerical integration of several tens simultaneous differentialequations, representing many types of molecular reactions. By applying variousmathematical tools to the model, principle mechanisms of cell function was clarified.
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