2013 Fiscal Year Final Research Report
Regulation of the aging by calorie restriction: Implications of mitochondrial retrograde signals
| Project/Area Number |
22390042
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Nagasaki University |
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Principal Investigator |
SHIMOKAWA Isao 長崎大学, 医歯(薬)学総合研究科, 教授 (70187475)
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| Co-Investigator(Kenkyū-buntansha) |
MORI Ryoichi 長崎大学, 大学院・医歯薬学総合研究科, 講師 (30509310)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | カロリー制限 / 老化 / ミトコンドリア |
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| Research Abstract |
Calorie restriction (CR) may exert anti-aging effects by modulating mitochondrial functions. We previously reported that CR upregulated mitochondrial proteins, including Cox6b1, a subunit of cytochrome c oxidase (Cox). To investigate the functional roles of Cox6b1 in mitochondria, we conducted in vitro experiments using Cox6b1-overexpressing cells or knockdown cells. The findings suggest that Cox6b1 mediates some of the effects, e.g., stress resistance, of CR by enhancing mitochondrial respiration via the assembly of Cox supercomplexes. The simultaneous generation of ROS may be prevented by several mechanisms, including Nrf2 activation. We also found that inhibition of glycogen synthase kinase (GSK)-3b, a putative upstream signaling molecule for Cox6b1, increased Cox6b1 protein expression. Accordingly, we confirmed that CR increased phosphorylated GSK-3b, its inactive form, in the mouse liver. The present study supports the mitohormesis hypothesis of CR.
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[Journal Article] Caloric restriction-associated remodeling of rat white adepose tissue : effects on the growth hormone/insulin-like growth factor-1 axis, sterol regulatory element binding protein-1, and macrophage infiltration2013
Author(s)
Chujo Y,Fujii N,Okita N,Konishi T, Yamada A,Haruyama Y,Tashiro K,Chiba T,Shimokawa I,Higami Y
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Journal Title
Age(Dordr)
Volume: Vol.35
Pages: 1143-1156
Peer Reviewed
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[Journal Article] M5総合病理CPC 記録 : 慢性呼吸不全により死亡した31歳男性2012
Author(s)
安井 万里子, 坂本 光, 新宮 啓太, 平 光寿, 高藤 康, 徳満 純一, 鳥山 愛生, 永田 祐貴, 難波 夏実, 道辻 徹, 高木 理博, 石田 正之, 有吉 紅也, 林 洋子, 下川 功
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Journal Title
長崎医学会雑誌
Volume: 87巻
Pages: 80-86
Peer Reviewed
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[Journal Article] Yamada K Hyperadiponectinemia protects against premature death in metabolic syndrome model mice by inhibiting AKT signaling and chronic inflammation2012
Author(s)
Otabe S,Wada N,Hahinaga T,Yuan X Shimokawa I,Fukutani T,Tanaka K, Ohki T,Kakino S,Kurita Y,Nakayama H, Tajiri Y
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Journal Title
J Endocrinol
Volume: Vol.213
Pages: 67-76
Peer Reviewed
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