2012 Fiscal Year Final Research Report
Roles of the prostanoids in the pathogenesis of cardiovascular diseases
| Project/Area Number |
22390045
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOJIMA Fumiaki 旭川医科大学, 医学部, 助教 (30550545)
KASHIWAGI Hitoshi 旭川医科大学, 医学部, 助教 (60510609)
YUHKI Koh-ichi 旭川医科大学, 医学部, 准教授 (80302420)
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| Project Period (FY) |
2010 – 2012
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| Keywords | プロスタノイド / プロスタグランジン / トロンボキサン / 循環器 |
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| Research Abstract |
To clarify the roles of the prostanoids in the cardiovascular system, we employed several animal models showing similar pathophysiology with those seen in human diseases. Through the analysis of these animal models, we found novel actions of the prostanoids, which include the role of the EP4 and IP in the development of renal interstitial fibrosis, the role of the EP1 in the development of cisplatin-induced nephropathy and the potent inhibitory action of ONO1301 on platelet aggregation._4 Au
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