2012 Fiscal Year Final Research Report
Chronic inflammation-induced mimRNA functional impairment may cause inflammation-associated tumorigenesis in gastroenterological organs.
| Project/Area Number |
22390058
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OTSUKA Motoyuki 東京大学, 医学部附属病院消化器内科, 助教 (90518945)
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| Co-Investigator(Kenkyū-buntansha) |
立石 敬介 東京大学, 医学部附属病院消化器内科, 助教 (20396948)
前田 愼 横浜市立大学, 医学系研究科, 教授 (40415956)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 分子腫瘍学 / microRNA / 炎症発癌 |
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| Research Abstract |
The novel concept “chronic impairment of microRNA function due to chronic inflammation may cause inflammation-associated tumorigenesis” was identified. Drug library screening revealed a compound which enhances microRNA function. This compound indeed had preventive effects against inflammation-associated tumorigenesis. These results may open a new strategy to prevent inflammation-associated tumorigenesis.
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Author(s)
Kumar V, Kato N, Urabe Y, Takahashi A, Muroyama R, Hosono N, Otsuka M, Tateishi R, Omata M, Nakagawa H, Koike K, Kamatani N, Kubo M, Nakamura Y, Matsuda K
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Journal Title
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Nat Commun
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