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2012 Fiscal Year Final Research Report

Glucose and lipid metabolism regulated by the endoplasmic reticulum signaling

Research Project

  • PDF
Project/Area Number 22390061
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathological medical chemistry
Research InstitutionThe University of Tokushima

Principal Investigator

OYADOMARI Seiichi  徳島大学, 疾患プロテオゲノム研究センター, 教授 (90502534)

Co-Investigator(Kenkyū-buntansha) HOSODA Akira  徳島大学, 疾患プロテオゲノム研究セン ター, 特任助教 (50379559)
OYADOMARI Miho  徳島大学, 疾患プロテオゲノム研究セン ター, 特任助教 (00596158)
MIYAKE Masato  徳島大学, 疾患プロテオゲノム研究セン ター, 特任助教 (30588976)
Project Period (FY) 2010 – 2012
Keywords小胞体 / ストレス / PERK / eIF2α / 代謝 / 骨格筋 / 褐色脂肪細胞
Research Abstract

The unfolded protein response (UPR) signal is involved in metabolic regulation. However, the significance of the protein kinase R-like endoplasmic reticulum kinase (PERK) signaling pathway in metabolism remains to be clarified. Our study showthat skeletal muscle-specific PERK activation promotes energy consumption in brown adipose tissue (BAT) and suppresses diet-induced obesity. We reveal that when eIF2αis phosphorylated by PERK, it acts through activating transcription factor 4 (ATF4) to stimulate energy consumption by inducing secretion of the myokine FGF21.

  • Research Products

    (7 results)

All 2012 2011 2010 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Remarks (1 results)

  • [Journal Article] Brown Rice and Its Component, γ-Oryzanol, Attenuate the Preference for High-Fat Diet by Decreasing Hypothalamic Endoplasmic Reticulum Stress in Mice2012

    • Author(s)
      Kozuka C, Oyadomari S
    • Journal Title

      Diabetes

      Volume: 61 Pages: 3084-93

    • DOI

      doi:10.2337/db11-1767

    • Peer Reviewed
  • [Journal Article] Nanosecond pulsed electric fields act as a novel cellular stress that induces translational suppression accompanied by eIF2αphosphorylation and 4E-BP1 dephosphorylation2012

    • Author(s)
      Morotomi-Yano K, Oyadomari S
    • Journal Title

      Exp Cell Res

      Volume: 318 Pages: 1733-1744

    • DOI

      doi:10.1016/j.yexcr.2012.04.016

    • Peer Reviewed
  • [Journal Article] CHOP deletion does not impact the development of diabetes but suppresses the early production of insulin autoantibody in the NOD mouse2011

    • Author(s)
      Sato T, Oyadomari S
    • Journal Title

      Apoptosis

      Volume: 16 Pages: 438-448

    • DOI

      doi:10.1007/s10495-011-0576-2

    • Peer Reviewed
  • [Journal Article] Involvement of Endoplasmic Stress Protein C/EBP Homologous Protein in Arteriosclerosis Acceleration With Augmented Biological Stress Responses2011

    • Author(s)
      Gao J, Oyadomari S
    • Journal Title

      Circulation

      Volume: 124 Pages: 830-839

    • DOI

      doi:10.1161/CIRCULATIONAHA.110.014050.

    • Peer Reviewed
  • [Journal Article] Influence of the hepatic eukaryotic initiation factor 2alpha (eIF2alpha) endoplasmic reticulum (ER) stress response pathway on insulin-mediated ER stress and hepatic and peripheral glucose metabolism2011

    • Author(s)
      Birkenfeld AL, Oyadomari S
    • Journal Title

      J Biol Chem

      Volume: 286 Pages: 36163-36170

    • DOI

      doi:10.1074/jbc.M111.228817.

    • Peer Reviewed
  • [Journal Article] Induction of liver steatosis and lipid droplet formation in ATF6alpha-knockout mice burdened with pharmacological endoplasmic reticulum stress2010

    • Author(s)
      Yamamoto K, Oyadomari S
    • Journal Title

      Mol Bio Cell

      Volume: 21 Pages: 2975-2986

    • DOI

      doi:10.1091/mbc.E09-02-0133

    • Peer Reviewed
  • [Remarks]

    • URL

      http://www.genome.tokushima-u.ac.jp/dmb/DMB/homu.html

URL: 

Published: 2014-08-29  

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