2012 Fiscal Year Final Research Report
Glucose and lipid metabolism regulated by the endoplasmic reticulum signaling
| Project/Area Number |
22390061
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
OYADOMARI Seiichi 徳島大学, 疾患プロテオゲノム研究センター, 教授 (90502534)
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| Co-Investigator(Kenkyū-buntansha) |
HOSODA Akira 徳島大学, 疾患プロテオゲノム研究セン ター, 特任助教 (50379559)
OYADOMARI Miho 徳島大学, 疾患プロテオゲノム研究セン ター, 特任助教 (00596158)
MIYAKE Masato 徳島大学, 疾患プロテオゲノム研究セン ター, 特任助教 (30588976)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 小胞体 / ストレス / PERK / eIF2α / 代謝 / 骨格筋 / 褐色脂肪細胞 |
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| Research Abstract |
The unfolded protein response (UPR) signal is involved in metabolic regulation. However, the significance of the protein kinase R-like endoplasmic reticulum kinase (PERK) signaling pathway in metabolism remains to be clarified. Our study showthat skeletal muscle-specific PERK activation promotes energy consumption in brown adipose tissue (BAT) and suppresses diet-induced obesity. We reveal that when eIF2αis phosphorylated by PERK, it acts through activating transcription factor 4 (ATF4) to stimulate energy consumption by inducing secretion of the myokine FGF21.
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