2012 Fiscal Year Final Research Report
Mechanisms underlying oncogenesis by deregulation of glycolysis andp53-mediated tumor suppression.
| Project/Area Number |
22390062
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Nippon Medical School |
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Principal Investigator |
TANAKA Nobuyuki 日本医科大学, 大学院・医学研究科, 教授 (80222115)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 分子腫瘍学 |
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| Research Abstract |
We found that tumor suppressor p53 hampers aerobic glycolysis, and that enhanced energy provision by loss of p53 is important for oncogenesis in vitro. To identify the role of enhanced glycolysis in cancer development in vivo, we analyzed these effects in colitis-induced colon cancer. In colitis tissues, glycolysis was enhanced by IL-6, and p53-induced cell growth suppression was attenuated, suggesting thatthese effects are important for tumorigenesis.
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[Journal Article] The role of the BH3-only protein Noxa in bone homeostasis.2011
Author(s)
Idrus, E., Nakashima, T., Wang, L., Hayashi, M., Okamoto, K., Kodama, T.,Tanaka, N., Taniguchi, T., and Takayanagi, H.
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Journal Title
Biochem Biophys Res Commun
Volume: 410
Pages: 620-625
Peer Reviewed
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[Journal Article] Interleukin 6 enhances glycolysis through expression of the glycolytic enzymes hexokinase 2 and6-phosphofructo-2-kinase/fructose-2,6-b isphosphatase-3.2010
Author(s)
Ando, M., Uehara, I., Kogure, K., Asano, Y., Nakajima, W., Abe, Y.,Kawauchi, K., and Tanaka, N.
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Journal Title
J Nippon Med Sch
Volume: 77
Pages: 97-105
Peer Reviewed
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