2012 Fiscal Year Final Research Report
Study on new approach to effective acquirement and the maintaining mechanisms of prostate cancer stem cell.
| Project/Area Number |
22390070
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Nara Medical University |
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Principal Investigator |
KONISHI Noboru 奈良県立医科大学, 医学部, 教授 (20145832)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMADA Keiji 奈良県立医科大学, 医学部, 講師 (90336850)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 前立腺 / 癌幹細胞 / 癌化 / CD133 / CD44 / syndecan-1 |
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| Research Abstract |
Increasing evidence suggests that tumor-initiating cells (TIC) contribute to the development of prostate cancer. We identify syndecan-1 as a key molecule for maintaining the stability of prostate cancer TIC. Holoclones harboring biological properties of stemness overexpressed syndecan-1, but showed reduced expression of NADPH oxidase and synthesis of hydrogen peroxide and oxygen radicals. In the transgenic adenocarcinoma of the mouse prostate (TRAMP) model of prostate cancer, early intervention with a syndecan-1 inhibitor (OGT2115) or syndecan-1 RNAi reduced the cancer incidence and the number of c-kit+/CD44+ cells. Syndecan-1 immunopositivity in prostate cancer cells was significantly associated with biochemical recurrence after radical prostatectomy. Taken together, syndecan-1 contributes to prostatic carcinogenesis by maintaining TIC, and might be a novel target molecule for effective cancer therapy.
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[Journal Article] Calculated Tumor Volume Is an Independent Predictor of Biochemical Recurrence in patients Who Underwent Retropubic Radical Prostatectomy2012
Author(s)
Tanaka, N., Fujimoto, K., Hirayama, A., Nakai, Y., Chihara, Y., Anai, S., Tomioka, A., Shimada, K., Konishi, N., Hirao, Y
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Journal Title
Peer Reviewed
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[Journal Article] Direct targeting of fibroblast growth factor-inducible 14 protein protects against renal ischemia reperfusion injury2011
Author(s)
Hotta, K., Sho, M., Yamato, I., Shimada, K., Harada, H., Akahori, T., Nakamura, S., Konishi, N., Yagita, H., Nonomura, K., Nakajima, Y
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Journal Title
Kidney Int
Volume: 79
Pages: 151-153
Peer Reviewed
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[Journal Article] Effects of minocycline on hind-limb motor function and gray and white matter injury after spinal cord ischemia in rats2011
Author(s)
Takeda, M., Kawaguchi, M., Kumatoriya, T., Horiuchi, T., Watanabe, K., Inoue, S., Konishi, N., Furuya, H
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Journal Title
Spine
Volume: 36
Pages: 1919-1924
Peer Reviewed
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[Journal Article] Risk-stratified survival rates and predictors of biochemical recurrence after radical prostatectomy in a Nara, Japan, cohort study2011
Author(s)
Tanaka, N., Fujimoto, K., Hirayama, A., Torimoto, K., Okajima, E., Tanaka, M., Miyake, M., Shimada, K., Konishi, N., Hirao, Y
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Journal Title
Int J Clin Oncol
Volume: 16
Pages: 553-559
Peer Reviewed
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[Journal Article] Prognostic significance of CD45RO+ memory T cells in renal cell carcinoma2011
Author(s)
Hotta, K., Sho, M., Fujimoto, K., Shimada, K., Yamato, I., Anai, S., Konishi, N., Hirao, Y., Nonomura, K., Nakajima, Y
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Journal Title
Br J Cancer
Volume: 105
Pages: 1191-1196
Peer Reviewed
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[Journal Article] Role of syndecan-1 (CD138) in cell survival of human urothelial carcinoma2010
Author(s)
Shimada, K., Nakamura, M., De Velasco MA, Tanaka, M., Ouji, Y., Miyake, M., Fujimoto, K., Hirao, K., Konishi, N
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Journal Title
Cancer Sci
Volume: 101
Pages: 155-160
Peer Reviewed
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[Journal Article] Posttreatment but not pretreatment with selective beta-adrenoreceptor 1 antagonists provides neuroprotection in the hippocampus in rats subjected to transient forebrain ischemia2010
Author(s)
Iwata, M., Inoue, S., Kawaguchi, M., Nakamura, M., Konishi, N., Furuya, H
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Journal Title
Anesth Analg
Volume: 110
Pages: 1126-1132
Peer Reviewed
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[Journal Article] ステージC前立腺癌症例における根治的前立腺全摘除術、外部照射放射線治療およびホルモン治療の治療成績2010
Author(s)
田中宣道, 冨岡厚志, 仲川嘉紀, 林美樹, 百瀬均, 三馬省二, 岡島英二郎, 藤本清秀, 平尾佳彦, 浅川勇雄, 玉本哲郎, 長谷川正俊, 小西 登
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Journal Title
泌尿器外科
Volume: 23
Pages: 1079-1082
Peer Reviewed
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[Journal Article] Variations in health-related quality of life in Japanese men who underwent iodine-125 permanent brachytherapy for localized prostate cancer2010
Author(s)
Tanaka, N., Fujimoto, K., Asakawa, I., Hirayama, A., Yoneda, T., Yoshida, K., Hirao, Y., Hasegawa M., Konishi, N
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Journal Title
Brachytherapy
Volume: 9
Pages: 300-306
Peer Reviewed
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[Presentation] 前立腺癌小線源治療後の排尿障害に対するα-1 ブロッカーの硬化-ナフトピジル・シロドシン対照試験2012
Author(s)
田中宣道, 堀 俊太, 森澤洋介, 篠原雅岳, 喜馬啓介, 穴井 智, 鳥本一匡, 平山暁秀, 藤本清秀, 浅川勇雄, 長谷川正俊, 小西 登, 平尾佳彦
Organizer
第100回日本泌尿器科学会総会
Place of Presentation
横浜
Year and Date
2012-04-21
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[Presentation] 前立腺癌初期 staging における骨シンチの有用性2010
Author(s)
田中宣道,大塚憲司, 富岡厚志,穴井 智,三宅牧人, 井上剛志, 池田朋博,松村善昭,山本雅司, 藤本清秀,平尾佳彦, 小西 登
Organizer
第26回前立腺シンポジウム
Place of Presentation
東京
Year and Date
2010-12-12
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[Presentation] A novel signal associated with reactive oxygen species for maintenance of prostate cancer stem cell-like population2010
Author(s)
Shimada, K., Anai, S., Fujimoto, K., Hirao, Y., Tasaki, M., Konishi, N
Organizer
第69回日本癌学会総会
Place of Presentation
大阪
Year and Date
2010-09-23
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[Presentation] Pre-clinical chemopreventive efficacy of chlormadinone acetate against prostate cancer2010
Author(s)
Koike, H., Marco A. De Velasco, Shimada, K., Yoshikawa, K., Arao, T., Nishio, K., Konishi, N., Uemura, H
Organizer
第69回日本癌学会総会
Place of Presentation
大阪
Year and Date
2010-09-23
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[Presentation] The phosphorylation status of FADD in biopsy specimens is associated with biochemical recurrence after prostatectomy2010
Author(s)
Marco A. De Velasco, Koike, H., Shimada, K., Yoshikawa, K., Konishi, N., Arao, T., Nishio, K., Uemura, H
Organizer
第69回日本癌学会総会
Place of Presentation
大阪
Year and Date
2010-09-23
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[Presentation] 前立腺全摘標本における Molecular Profileによる再発予測2010
Author(s)
穴井 智,井上剛志, 三宅牧人,池田朋博,富岡厚志,桑田真臣,松村善昭,谷 善啓,田中宣道,藤本清秀,平尾佳彦,島田啓司,小西 登
Organizer
第98回日本泌尿器科学会総会
Place of Presentation
盛岡
Year and Date
2010-04-27
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