Identification of cardiomyogenic factor in terms of cell-based therapy/regenerative medicine

2014 Fiscal Year Final Research Report

• Project/Area Number: 22390072
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Human pathology
• Research Institution: National Research Institute for Child Health and Development
• Principal Investigator: UMEZAWA Akihiro 独立行政法人国立成育医療研究センター, 再生医療センター, センター長 (70213486)
• Co-Investigator(Kenkyū-buntansha): KURODA Masahiko 東京医科大学, 病理学教室, 教授 (80251304) ; TOYODA Masashi 地方独立行政法人東京都健康長寿医療センター, 研究所老年病研究チーム, 研究副部長
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: 細胞・組織 / タンパク質 / 心筋再生 / 液性因子 / 再生医療

Outline of Final Research Achievements

We examined mesenchymal cells with an extended life span to investigate cardiomyogenic factors comprehensively. Among the mesenchymal cells, we focused on CD29-high CD34-low c-kit-positive CD140a-positive cells, and established a method to select cells capable of differentiating into cardiomyocytes in a high frequency. We implanted mesenchymal cells derived from a series of tissues including placenta into injured hearts. We herewith report to generate an experimental design to obtain proof of concept in a pre-clinical setting for cell-based therapy using tissue-derived mesenchymal cells to injured hearts.

Free Research Field

幹細胞生物学