2013 Fiscal Year Final Research Report
Regulation of environmental responses and its physiological significance in Vibrio species
| Project/Area Number |
22390086
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Hosei University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SOWA Yoshiyuki 法政大学, 生命科学部, 専任講師 (10519440)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | コレラ菌 / 海洋ビブリオ菌 / 走化性 / シグナル伝達 / 受容体 / 二成分制御系 |
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| Research Abstract |
We have identified two amino acid receptors of Vibrio cholerae for chemotaxis, one of which also senses taurine, a major component of bile. The taurine response and the expression of the taurine chemoreceptor was enhanced at elevated temperature, raising an intriguing possibility that taurine taxis play a role in pathogenesis of the bacteria. We also identified an amino acid chemoreceptor in marine Vibrio sp., the expression of which may be induced coordinately with lateral flagella. We also found that chemotaxis-related signaling proteins localized to a cell pole under micro aerobic conditions, implying that these signaling systems function under specific conditions such as in the host intestine.
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[Journal Article] Mlp24 (McpX) of Vibrio cholerae implicated in pathogenicity functions as a chemoreceptor for multiple amino acids2012
Author(s)
Nishiyama, S., Suzuki, D., Ito, Y., Suzuki, K., Tajima, H., Hyakutake, A., Homma, M., Butler-Wu, S. M., Camilli, A., and Kawagishi, I
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Journal Title
Infect. Immun
Volume: 80
Pages: 3170-3178
Peer Reviewed
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[Journal Article] Ligand specificity determined by differentially arranged common ligand-binding residues in the bacterial amino acid chemoreceptors Tsr and Tar2011
Author(s)
Tajima, H., Imada, K., Sakuma, M., Hattori, F., Sumii, M., Nara, T., Kamo, N., Homma, M., and Kawagishi, I
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Journal Title
J. Biol. Chem
Volume: 286
Pages: 4220-42210
Peer Reviewed
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[Presentation] Structure of a chemoreceptor protein of Vibrio cholerae, Mlp24, and its ligand complex2013
Author(s)
Takahashi, T., Sumita, K., Uchida, Y., Nishiyama, S., Kawagishi I., Imada, K
Organizer
日本生物物理学会第51回年会
Place of Presentation
京都国際会館(京都府)
Year and Date
20131028-30
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[Presentation] Identification of a novel transducer for amino acid taxis in the marine bacterium Vibrio alginolyticus2013
Author(s)
Tsuji, Y., Konishi, M., Nishiyama, S., Kojima, K., Sowa, Y., Kawagishi, I.
Organizer
日本生物物理学会第51回年会
Place of Presentation
京都国際会館(京都府)
Year and Date
20131028-30
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[Presentation] Chemoreceptor-like proteins of Vibrio cholerae, each with a single periplasmic PAS-like domain, thatmediate taxis toward amino acids2012
Author(s)
Kawaguchi, T., Yamamoto-Tamura, K., Nishiyama, S., and Kawagishi, I.
Organizer
Receptor Fest XV
Place of Presentation
University of Colorado, Boulder(アメリカ合衆国コロラド州)
Year and Date
20120805-06
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[Presentation] Mechanisms of ligand recognition by the amino acid chemoreceptors of Vibrio cholerae2011
Author(s)
Nishiyama, S., Yamamoto, K., Tajima. H., Kawaguchi, T., Sekiguchi, H., and Kawagishi, I.
Organizer
第49回日本生物物理学会年会
Place of Presentation
兵庫県立大学姫路書写キャンパス (兵庫県)
Year and Date
2011-09-16
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