2012 Fiscal Year Final Research Report
Research on release mechanism, genome mutations and cellular receptor of hepatitis E virus (HEV) using cell culture systems for HEV
| Project/Area Number |
22390090
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAGASHIMA Shigeo 自治医科大学, 医学部, 講師 (60433116)
TAKAHASHI Masaharu 自治医科大学, 医学部, 講師 (70326841)
KOBAYASHI Tominari 自治医科大学, 医学部, 助教 (00634164)
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| Project Period (FY) |
2010 – 2012
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| Keywords | E型肝炎ウイルス / 感染培養系 / 感染性 cDNA クローン / 感受性細胞 / 吸着 / 細胞レセプター候補分子 |
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| Research Abstract |
Utilizing our efficient cell culture systems for hepatitis E virus (HEV), we elucidated that the ORF3 protein with an intact PSAP motif as well as Tsg101 and Vps4 as host factors are essential for the formation and release of membrane-associated HEV parti
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[Journal Article] Molecular epidemiology and genetic history of European-type genotype 3 hepatitis E virus indigenized in the central region of Japan2012
Author(s)
Nakano T, Okano H, Kobayashi M, Ito K, Ohmori S, Nomura T, Kato H, Ayada M, Nakano Y, Akachi S, Sugimoto K, Fujita N, Shiraki K, Takei Y, Takahashi M, Okamoto H
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Journal Title
Infect Genet Evol
Volume: 12(7)
Pages: 1524-34
Peer Reviewed
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[Journal Article] New findings regarding the epidemic history and population dynamics of Japan-indigenous genotype 3 hepatitis E virus inferred by molecular evolution2012
Author(s)
Nakano T, Takahashi K, Pybus OG, Hashimoto N, Kato H, Okano H, Kobayashi M, Fujita N, Shiraki K, Takei Y, Ayada M, Arai M, Okamoto H, Mishiro S.
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Journal Title
Liver Int
Volume: 32(4)
Pages: 675-88
Peer Reviewed
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[Journal Article] A nationwide survey of hepatitis E virus (HEV) infection in wild boars in Japan: identification of boar HEV strains of genotypes 3 and 4 and unrecognized genotypes2011
Author(s)
Sato Y, Sato H, Naka K, Furuya S, Tsukiji H, Kitagawa K, Sonoda Y, Usui T, Sakamoto H, Yoshino S, Shimizu Y, Takahashi M, Nagashima S, Jirintai, Nishizawa T, Okamoto H.
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Journal Title
Arch Virol
Volume: 156(8)
Pages: 1345-58
Peer Reviewed
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[Journal Article] Hepatitis E Virus (HEV) strains in serum samples can replicate efficiently in cultured cells despite the coexistence of HEV antibodies: characterization of HEV virions in blood circulation2010
Author(s)
Takahashi M, Tanaka T, Takahashi H, Hoshino Y, Nagashima S, Jirintai, Mizuo H, Yazaki Y, Takagi T, Azuma M, Kusano E, Isoda N, Sugano K, Okamoto H.
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Journal Title
J Clin Microbiol
Volume: 48(4)
Pages: 1112-25
Peer Reviewed
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[Journal Article] A nationwide survey of hepatitis E virus infection in the general population of Japan2010
Author(s)
Takahashi M, Tamura K, Hoshino Y, Nagashima S, Yazaki Y, Mizuo H, Iwamoto S, Okayama M, Nakamura Y, Kajii E, Okamoto H.
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Journal Title
J Med Virol
Volume: 82(2)
Pages: 271-81
Peer Reviewed
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[Journal Article] A high genomic similarity between European type hepatitis E virus subgenotype 3e Jirintai S, Jinshan, Tanggis, Manglai 18. strains isolated from an acute hepatitis patient and a wild boar in Mie, Japan
Author(s)
Okano H, Nakano T, Sugimoto K, Takahashi K, Nagashima S, Takahashi M, Arai M, Okamoto H
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Journal Title
Jinshan, Tanggis, Manglai
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[Presentation] Tsg101 and vacuolar protein sorting pathway are required for virion release of hepatitis E virus2011
Author(s)
Nagashima, S., Takahashi, M., Jirintai, Tanaka, T., Nishizawa, T., Yasuda J, Okamoto, H
Organizer
XV International Congress of Virology
Place of Presentation
Sapporo
Year and Date
20110911-16
