2013 Fiscal Year Final Research Report
The molecular basis of PSGL-1-dependent viral replication and pathogenesis in enterovirus 71 infection
| Project/Area Number |
22390092
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
SHIMIZU HIROYUKI 国立感染症研究所, ウイルス第二部, 室長 (90270644)
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| Co-Investigator(Renkei-kenkyūsha) |
NISHIMURA Yorihiro 国立感染症研究所, ウイルス第二部 第二室, 主任研究官 (00392316)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | エンテロウイルス / 受容体 / エンテロウイルス71 / PSGL-1 / 感染モデル / 手足口病 / レセプター |
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| Research Abstract |
Enterovirus 71 (EV71) is a major causative agent of hand, foot, and mouth disease, and causes various neurological diseases, including fatal encephalitis. In this study, we investigated the molecular basis of the interaction between EV71 and PSGL-1, a functional cellular receptor for EV71. We demonstrated that tyrosine sulfation at the N-terminal region of PSGL-1 plays a critical role in the PSGL-1-binding to EV71. An amino acid residue of the capsid protein VP1 of EV71 (VP1-145) controls virus tropism by changing the accessibility of VP1-244 to the sulfated N-terminus of PSGL-1, thus suggesting the involvement of VP1-145 in a PSGL-1-dependent viral replication and pathogenesis in EV71 infection.
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[Journal Article] Clinical manifestations of coxsackievirus A6 infection associated with a major outbreak of hand, foot, and mouth disease in Japan2013
Author(s)
Kobayashi M, Makino T, Hanaoka N, Shimizu H, Enomoto M, Okabe N, Kanou K, Konagaya M, Oishi K, Fujimoto T
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Journal Title
Jpn J Infect Dis
Volume: 66
Pages: 260-261
DOI
Peer Reviewed
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[Journal Article] Enterovirus 71 encephalomyelitis and Japanese encephalitis can be distinguished by topographic distribution of inflammation and specific intraneuronal detection of viral antigen and RNA in the central nervous system2012
Author(s)
Wong KT, Ng KY, Ong KC, Ng WF, Shankar SK, Mahadevan A, Radotra B, Su JI, Lau G, Ling AE, Chan KP, Macorelles P, Desai AS, Ravi V, Nagata N, Shimizu H, Takasaki T
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Journal Title
Neuropath Appl Neuro
Volume: 38(1365-2990.2011.01247.x)
Pages: 443-453
Peer Reviewed
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[Journal Article] Hand, Foot, and Mouth Disease Caused by Coxsackievirus A6, Japan, 20112012
Author(s)
Fujimoto T, Iizuka S, Enomoto M, Abe K, Yamashita K, Hanaoka N, Okabe N, Yoshida H, Yasui Y, Kobayashi M, Fujii Y, Tanaka H, Yamamoto M, Shimizu H
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Journal Title
Emerg Infect Dis
Volume: 18
Pages: 337-339
DOI
Peer Reviewed
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