2012 Fiscal Year Final Research Report
Molecular mechanisms for affinity-based selection, development and maintenance of memory B cells.
| Project/Area Number |
22390097
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | B 細胞 / 免疫応答 / 免疫学的記憶 / B 細胞 / 胚中心 / 親和性成熟 |
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| Research Abstract |
Elucidation of molecular mechanisms for development and maintenance of memory B cells is important for development of efficient vaccination and protective immunity. During immune responses, B cells that bind antigens with a high affinity are selected in the germinal centers of peripheral lymphoid tissues, develop into memory B cells, and maintained for a long time, mechanisms for which have largely been unknown. In this study, we utilized the induced germinal center B (iGB) cell culture system, and identified candidates for the factors involved in the development and maintenance of memory B cells.
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[Journal Article] In-vitro derived germinal centre B cells differentially generate memory B or plasma cells in vivo2011
Author(s)
Nojima, T., Haniuda, K., Moutai, T., Matsudaira, M., Mizokawa, S., Shiratori, I., Azuma, T. and Kitamura, D
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Peer Reviewed
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