Pathogenesis of depression and its treatment strategy: a PET study

2012 Fiscal Year Final Research Report

• Project/Area Number: 22390110
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied pharmacology
• Research Institution: Chiba University
• Principal Investigator: SEKINE Yoshimoto 千葉大学, 社会精神保健教育研究センター, 教授 (70324358)
• Co-Investigator(Kenkyū-buntansha): KANARAHA Nobuhisa 千葉大学, 社会精神保健教育研究センター, 講師 (70507350)
• Project Period (FY): 2010 – 2012
• Keywords: 薬物治療学 / 治療合理化 / うつ病 / PET / ミクログリア

Research Abstract

Depression is a popular psychiatric disease and it's prevalence rate is estimated about 15% in the world. The remission rate of depression is not sufficient, although new generation antidepressants, such as serotonin and/or noradrenalin selective reuptake inhibitors are used. In this study, we found that microglial activation might be occurred in the brains of depressive patient. Furthermore, the treatment with anti-inflammatory minocycline was effective in such a patient. These findings suggest that microglial activation might be associated with the pathogenesis of depressed patients, and that minocycline could be an effective agent for the treatment in people with depressive state.

Research Products

• [Journal Article] Orbitofrontal cortex abnormality and deficit schizophrenia (2013)
  • Author(s): Kanahara N, Sekine Y, Haraguchi T, Uchida Y, Hashimoto K, Shimizu E, Iyo M
  • Journal Title: Schizophr Res. Volume: 143(2-3) Pages: 246-52
• [Journal Article] Chronic treatment with aripiprazole prevents development of dopamine supersensitivity and potentially supersensitivity psychosis (2012)
  • Author(s): Tadokoro S, Okamura N, Sekine Y, Kanahara N, Hashimoto K, Iyo M
  • Journal Title: Schizophr Bull Volume: 38(5) Pages: 1012-20
• [Journal Article] Association analysis of the tryptophan hydroxylase 2 gene polymorphisms in patients with methamphetamine dependence/psychosis (2011)
  • Author(s): Kobayashi H, Ujike H, Iwata N, Inada T, Yamada M, Sekine Y, Uchimura N, Iyo M, Ozaki N, Itokawa M, Sora I
  • Journal Title: Curr Neuropharmacol Volume: 9(1) Pages: 176-82
• [Journal Article] (2011)
  • Author(s): Kobayashi H, Ujike H, Iwata N, Inada T, Yamada M, Sekine Y, Uchimura N, Iyo M, Ozaki N, Itokawa M, Sora I
  • Journal Title: Curr Neuropharmacol Volume: 9(1) Pages: 137-42
• [Journal Article] A case of methamphetamine use disorder treated with the antibiotic drug minocycline (2010)
  • Author(s): Tanibuchi Y, Shimagami M, Fukami G, Sekine Y, Iyo M, Hashimoto K
  • Journal Title: Gen Hosp Psychiatry Volume: 32(5) Pages: 559.e1-3
• [Journal Article] The adenosine A2A receptor is associated with methamphetamine dependence/psychosis in the Japanese population (2010)
  • Author(s): Kobayashi H, Ujike H, Iwata N, Inada T, Yamada M, Sekine Y, Uchimura N, Iyo M, Ozaki N, Itokawa M, Sora I
  • Journal Title: Behav Brain Funct Volume: 30;6 Pages: 50
• [Book] 覚せい剤精神病 (2011)
  • Author(s): 関根吉統.松下正明総編集
  • Publisher: 中山書店,東京
• [Book] ドパミン・トランスポーター (2011)
  • Author(s): 関根吉統.松下正明総編集
  • Publisher: 中山書店, 東京
• [Remarks] 上記URLにおいて研究内容を公開した。
  • URL: http://www.m.chiba-u.ac.jp/class/shakai/jp/syakaifukki/kenkyu.html