2012 Fiscal Year Final Research Report
Study on oxidative stress and glial activation explaining demyelination in the central nervous system induced by alternative to freons
| Project/Area Number |
22390120
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Nagoya University |
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Principal Investigator |
ICHIHARA Gaku 名古屋大学, 医学系研究科, 准教授 (90252238)
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| Co-Investigator(Kenkyū-buntansha) |
TOYOKUNI Shinya 名古屋大学, 医学系研究科, 教授 (90252460)
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| Project Period (FY) |
2010 – 2012
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| Keywords | フロン代替物質 / 酸化ストレス |
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| Research Abstract |
Exposure to 1-bromopropane (1BP) induced oxidative stress as well as activating astrocyte and microglia in the cerebellum of rats. Exposure to 1BP also promoted carbonylation of various proteins including triosephosphateisomerase (TPI), decreased TPI activity and increased advanced glycation endproduct. The study suggested oxidative stress might be involved in toxicity of 1BP to the central nervous system.
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