2012 Fiscal Year Final Research Report
Molecular mechanism of infection/inflammation-associatedcarcinogenesis and cancer prevention
| Project/Area Number |
22390121
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Mie University |
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Principal Investigator |
MURATA Mariko 三重大学, 大学院・医学系研究科, 教授 (10171141)
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| Co-Investigator(Kenkyū-buntansha) |
OIKAWA Shinji 三重大学, 大学院・医学系研究科, 准教授 (10277006)
HIRAKU Yusuke 三重大学, 大学院・医学系研究科, 講師 (30324510)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 炎症 / 発がん / 活性酸素・窒素 / 8-ニトログアニン / 幹細胞 |
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| Research Abstract |
Chronic inflammation induced by biological, chemical, and physical factors has been found to be associated with the increased risk of cancer. We revealed that the nuclear localization of COX-2, which was reported to function as a transcription factor, was significantly associated with the up-regulation of stem cell marker in cancer tissues with parasite infection. COX-2 activation may be involved in stem cell proliferation/differentiation in inflammation-mediated carcinogenesis. 8-Nitroguanine was formed in stem cell marker-positive cells in inflammation-associated cancer tissues. Inflammation may increase the number of mutant stem cells, in which iNOS-dependent DNA damage occurs via NF-κB activation, leading to tumor development.
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[Journal Article] Proton pump inhibitors suppress iNOS-dependent DNA damage in Barrett's esophagus by increasing Mn-SOD expression.2012
Author(s)
Thanan R, Ma N, Iijima K, Abe Y, Koike T,Shimosegawa T, Pinlaor S,Hiraku Y, Oikawa S, Murata M, Kawanishi S
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Journal Title
Biochem Biophys Res Commun
Volume: 421(2)
Pages: 280-5
Peer Reviewed
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[Journal Article] Inflammation-induced protein carbonylation contributes to poor prognosis of cholangiocarcinoma.2012
Author(s)
Thanan R, Oikawa S, Yongvanit P, Hiraku Y, Ma N, Pinlaor S, Pairojkul C, Wongkham C, Sripa B, Khuntikeo N, Kawanishi S, Murata M
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Journal Title
Free Radic. Biol. Med
Volume: 52(8)
Pages: 1465-72
Peer Reviewed
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[Journal Article] Proton pump inhibitors suppress iNOS-dependent DNA damage in Barrett's esophagus by increasing Mn-SOD expression2012
Author(s)
Thanan R, Ma N, Iijima K, Abe Y, Koike T, Shimosegawa T, Pinlaor S, Hiraku Y, Oikawa S, Murata M, Kawanishi S
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Journal Title
Biochem. Biophys. Res. Commun
Volume: 421
Pages: 280-285
Peer Reviewed
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[Journal Article] Nitrative DNA damage and Oct3/4 expression in urinary bladder cancer with Schistosomahaematobium infection2011
Author(s)
Ma N, Thanan, R, Kobayashi H, Hammam O, Wishahi M, Leithy TE,Hiraku Y、Amro el K, Oikawa S, Ohnishi S, Murata M、Kawanishi S
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Journal Title
Biochem. Biophys. Res. Commun
Volume: 414
Pages: 344-349
Peer Reviewed
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[Journal Article] Proteomic identification of hippocampal proteins vulnerable to oxidative stress in excitotoxin-induced acute neuronal injury2011
Author(s)
Furukawa A, Kawamoto Y, Chiba Y, Takei S, Hasegawa-Ishii S, Kawamura N, Yoshikawa K, Hosokawa M, Oikawa S, Kato M, Shimada A
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Journal Title
Neurobiol Dis
Volume: 43
Pages: 706-714
Peer Reviewed
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[Journal Article] TFPI-2 is a putative tumor suppressor gene frequently inactivated by promoter hypermethylation in nasopharyngeal carcinoma2010
Author(s)
Wang S, Xiao X, Zhou X, Huang T, Du C, Yu N, Mo Y, Lin L, Zhang J, Ma N, Murata M, Huang G, Zhang Z
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Journal Title
BMC Cancer
Volume: 9;10
Pages: 617
Peer Reviewed
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[Journal Article] Oxidatively generated DNA damage induced by 3-amino-5-mercapto-1,2,4-triazole, a metabolite of carcinogenic amitrole.2010
Author(s)
Furukawa A, 査読有Oikawa S, Harada K, Sugiyama H, Hiraku Y, Murata M, Shimada A, Kawanishi S
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Journal Title
Mutat Res.
Volume: 694(1-2)
Pages: 7-12
Peer Reviewed
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[Journal Article] High incidence of tumors in diabetic thrombin activatable fibrinolysis inhibitor and apolipoprotein E double deficient mice2010
Author(s)
Beppu T, Gil-Bernabe P, Boveda-Ruiz D, D'Alessandro-Gabazza C, Matsuda Y, Toda M, Miyake Y, Shiraki K,Murata M、Murata T, Yano Y, Morser J, Gabazza EC, Takei Y.
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Journal Title
J Thromb Haemost.
Volume: 8(11)
Pages: 2514-22
Peer Reviewed
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[Journal Article] Romidepsin (FK228), a potent histone deacetylase inhibitor, induces apoptosis through the generation of hydrogen peroxide.2010
Author(s)
Mizutani H,Hiraku Y,Tada-Oikawa S, Murata M, Ikemura K, Iwamoto T, Kagawa Y, Okuda M, Kawanishi S.
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Journal Title
Cancer Sci
Volume: 101(10)
Pages: 2214-9
Peer Reviewed
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[Presentation] Cytosine methylation in EBV-mediated nasopharyngeal carcinoma in relati on to nitrative stress.2012
Author(s)
Yingxi Mo, Ning Ma, Shumin Wang, Zhe Zhang, Ying Xie, Guangwu Huang, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa Shosuke Kawanishi, Mariko Murata
Organizer
The 7th International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide
Place of Presentation
Edinburgh, UK
Year and Date
20120722-26
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[Presentation] Protein carbonylation in liver fluke-induced cholangiocarcinoma in relation to poor prognosis2012
Author(s)
Raynoo Thanan, Shinji Oikawa, Puangrat Yongvanit, Yusuke Hiraku, Ning Ma, Somchai Pinlaor, Chawalit Pairojkul, Chaisiri Wongkham, Banchob Sripa, Shosuke Kawanishi and Mariko Murata.
Organizer
Mahidol International Conference on Infection and Cancer
Place of Presentation
Bangkok, Thailand
Year and Date
20120206-08
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