2013 Fiscal Year Final Research Report
Comprehensive evaluation of female hormonal drugs in prospective women cohort study
| Project/Area Number |
22390128
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | 健康管理 / コホート研究 / 女性の健康 / ホルモン補充療法 / 乳癌 |
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| Research Abstract |
The Japan Nurses' Health Study (JNHS) is a prospective cohort investigation of the effects of lifestyle and healthcare on women's health. Data from the JNHS 4-year follow-up were used to investigate the use of postmenopausal hormone replacement therapy (HRT) and its effect on breast cancer in 13,479 Japanese nurses. The prevalence of HRT user was 16.0% (current user 7.1%) at baseline survey and 11.5 % (current user 3.6%) at 4-year follow-up survey.
We identified 77 breast cancer cases during 4-year follow-up period. The 44 cases (57%) were premenopausal women. The relative risk of breast cancer to premenopausal women were 0.60 in HRT non-users, 0.70 in HRT current users, and 0.61 in HRT ex-users. The breast cancer risk was likely to reduce after menopause, irrespective HRT use, suggesting that short duration of HRT use does not increase the breast cancer risk in Japanese women.
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