2013 Fiscal Year Final Research Report
Worksite-based cohort study on risk factors for non-communicable disease in Japan
| Project/Area Number |
22390133
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Fujita Health University (2012-2013)
Nagoya University (2010-2011) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
AOYAMA Atsuko 名古屋大学, 医学系研究科, 教授 (40184056)
TAMAKOSHI Koji 名古屋大学, 医学系研究科, 教授 (30262900)
LI Yuanying 名古屋大学, 医学系研究科, 教授 (20701288)
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| Research Collaborator |
TOYOSHIMA Hideaki 名古屋大学, 医学系研究科, 名誉教授 (10023657)
HIWASA Takaki 千葉大学, 医学系研究科, 准教授 (30260251)
CHIANG Chifa 名古屋大学, 医学系研究科, 助教 (20713887)
UEMURA Mayu 名古屋大学, 医学系研究科, 医学博士課程大学院生
HILAWE Esayas 名古屋大学, 医学系研究科, 医学博士課程大学院生
WANG Chaochen 名古屋大学, 医学系研究科, 医学博士課程大学院生
FOLSOM Aaron University of Minnesota, Professor
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | 生活習慣病 / コホート研究 / 心血管疾患 / 糖尿病 / 職域 / バイオマーカー |
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| Research Abstract |
We carried out a worksite-based cohort study in an attempt to identify risk factors and novel markers of cardiovascular disease in recent Japanese population. Civil servants of a local government located in central Japan (n=6,648) were followed, and 59 incident coronary heart diseases, 47 strokes, 430 diabetes, and 1,599 hypertension were ascertained during the entire observation period (approximately 10 years). Overweight, hypertension, and current smoking were significantly positively associated with higher incidence of cardiovascular disease. Low adiponectin and high CRP blood levels, current smoking, breakfast skipping, and positive family history were associated with higher diabetes incidence. Novel biomarkers were obtained by AlphaLISA. We also performed questionnaire survey and collected additional blood and urine sample for the remaining and new cohort participants (n=6,046).
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Research Products
(38 results)
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[Journal Article] Independent association of liver fat accumulation with insulin resistance2013
Author(s)
Yatsuya H, Nihashi T, Li Y, Hotta Y, Matsushita K, Muramatsu T, Otsuka R, Matsunaga M, Yamashita K, Wang C, Uemura M, Harada A, Fukatsu H, Toyoshima H, Aoyama A, Tamakoshi K
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Journal Title
DOI
Peer Reviewed
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[Journal Article] Associations of protein, fat, and carbohydrate intakes with insomnia symptoms among middle-aged Japanese workers2013
Author(s)
Tanaka E, Yatsuya H, Uemura M, Murata C, Otsuka R, Toyoshima H, Tamakoshi K, Sasaki S, Kawaguchi L, Aoyama A
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Journal Title
J Epidemiol
Volume: 23
Pages: 132-8
DOI
Peer Reviewed
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[Presentation] Parental histories and the incidence of diabetes, findings from a Japanese worksite-based cohort2014
Author(s)
Wang C, Yatsuya H, Tamakoshi K, Toyoshima H, Wada K, Li Y, Hilawe EH, Uemura M, Chiang C, Yan Z, Aoyama A
Organizer
第24回日本疫学会学術総会
Place of Presentation
仙台
Year and Date
2014-01-25
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[Presentation] Smoking and diabetes; Is the association mediated by adiponectin, leptin or C-reactive protein?2014
Author(s)
Hilawe EH, Yatsuya H, Li Y, Uemura M, Wang C, Chiang C, Toyoshima H, Tamakoshi K, Yan Z, Aoyama A
Organizer
第24回日本疫学会学術総会
Place of Presentation
仙台
Year and Date
2014-01-24
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[Presentation] 中高年齢者の朝食欠食とその後9年間の2型糖尿病発症との関連2014
Author(s)
上村真由, 八谷寛, 李媛英, 江啓発, 王超辰, Hilawe EH, 大塚礼, 豊嶋英明, 玉腰浩司, 張燕, 青山温子
Organizer
第24回日本疫学会学術総会
Place of Presentation
仙台
Year and Date
2014-01-24
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[Presentation] 肥満度およびメタボリックシンドローム構成要素数と9年間の2型糖尿病発症の関連2012
Author(s)
上村真由, 八谷寛, 川口レオ, 樋口倫代, 王超辰, 江啓発, 李媛英, 大塚礼, 和田恵子, 豊嶋英明, 玉腰浩司, 青山温子
Organizer
第71回日本公衆衛生学会総会
Place of Presentation
山口
Year and Date
2012-10-25
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[Presentation] 前糖尿病者における加糖清涼飲料水の摂取は2 型糖尿病発症リスクを有意に高める2012
Author(s)
上村真由, 八谷寛, 川口レオ, 樋口倫代, 王超辰, 江啓発, 李媛英, 大塚礼, 和田恵子, 豊嶋英明, 玉腰浩司, 佐々木敏, 青山温子
Organizer
第58回東海公衆衛生学会
Place of Presentation
津
Year and Date
2012-07-21
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[Presentation] Association of Intrahepatic Fat Quantified by 1H-magnetic Resonance Spectroscopy with Insulin Resistance in Middle-aged Japanese2011
Author(s)
Yatsuya H, Wang C, Nihashi T, Muramatsu T, Tamakoshi K, Li Y, Matsushita K, Hotta Y, Otsuka R, Fukatsu H, Toyoshima H
Organizer
The Ninth International Symposium on In Vivo Body Composition Studies
Place of Presentation
Hangzhou, China
Year and Date
2011-05-23
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[Presentation] Positive Association between blood C3 Level and Liver Fat Content Quantified by 1H Magnetic Resonance Spectroscopy in Japanese Men2011
Author(s)
Wang C, Yatsuya H, Nihashi T, Muramatsu T, Tamakoshi K, Li Y, Matsushita K, Hotta Y, Fukatsu H, Toyoshima H
Organizer
The Ninth International Symposium on In Vivo Body Composition Studies
Place of Presentation
Hangzhou, China
Year and Date
2011-05-22
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