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2013 Fiscal Year Final Research Report

Potential mechanisms and therapeutic strategies of sarcopenia

Research Project

  • PDF
Project/Area Number 22390143
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionNagoya University

Principal Investigator

KUZUYA Masafumi  名古屋大学, 医学(系)研究科(研究院), 教授 (10283441)

Co-Investigator(Renkei-kenkyūsha) CHENG Xian Wu  名古屋大学, 医学系研究科, 特任准教授 (30378228)
Project Period (FY) 2010-04-01 – 2014-03-31
Keywords老化 / サルコペニア / 動物
Research Abstract

To examine the effect of bone marrow stem cells as well as exercise on the age-associated skeletal muscle atrophy and weakness (sarcopenia), senescence-accelerated-prone mouse (SAMP10) were transplanted with bone marrow of wild-type (C57BL/6) at 8 weeks of age. Control non-transplant and transplant SMAP10 were randomly assigned to 2 groups with or without exercise training (from 25 weeks of age). At 40 weeks of age, muscle weight, endurance capacity, and the tissue biochemical analysis were carried out.
These studies provide the evidences that the bone marrow-derived stem cells differentiate into skeletal muscle cells. Bone marrow transplantation of wild type mice improves the age-associated skeletal muscle atrophy and weakness (sarcopenia), suggesting that aging of bone marrow cells may contribute to the cause of sarcopenia of SAMP10. In addition, exercise can prevent sarcopenia through the prevention of muscle protein degradation and mitochondrial activation in SAMP10.

  • Research Products

    (7 results)

All 2014 2013 2012

All Journal Article (4 results) (of which Peer Reviewed: 1 results) Presentation (3 results)

  • [Journal Article] β-Hydroxy-β- methylbutyrate facilitates PI3K/Aktdependent mammalian target of rapamycin and FoxO1/3a phosphorylations and alleviates tumor necrosis factor α/ interferon γ-induced MuRF-1 expression in C2C12 cells2014

    • Author(s)
      Kimura K, Cheng XW, Inoue A, Hu L, Koike T, Kuzuya M
    • Journal Title

      Nutr Res

      Volume: 34(4) Pages: 368-74

    • DOI

      10.1016/j.nutres.2014.02.003

    • Peer Reviewed
  • [Journal Article] サルコぺニアー成因と対策病因 原発生ならびに二次性サルコぺニアと動物モデル2014

    • Author(s)
      葛谷 雅文
    • Journal Title

      医学のあゆみ

      Volume: 248(9) Pages: 696-700

  • [Journal Article] サルコペニアと栄養2013

    • Author(s)
      葛谷 雅文
    • Journal Title

      腎と骨代謝

      Volume: 26(2) Pages: 135-141

  • [Journal Article] サルコペニア予防・治療と栄養の考え方(Q&A)2012

    • Author(s)
      葛谷 雅文
    • Journal Title

      医事新報

      Volume: No. 4600 56-57 Pages: 6.23

  • [Presentation] C2C12細胞におけるタンパク分解に対するHMB の効果atrogin-1,MuRFの発現とその制御に関して2014

    • Author(s)
      木村 薫, 成 憲武, 井上 愛子, 胡 麗娜, 葛谷 雅文
    • Organizer
      第29回日本静脈経腸栄養学会学術集会
    • Place of Presentation
      横浜市パシフィコ横浜
    • Year and Date
      2014-02-27
  • [Presentation] サルコペニアとは?そのoverview2013

    • Author(s)
      葛谷 雅文
    • Organizer
      第23回日本老年医学会九州地方会シンポジウム 「オムニバスシンポジオウム : 高齢者サルコペニアの病態と治療」
    • Place of Presentation
      福岡市 九州大学医学部百年講堂
    • Year and Date
      2013-03-09
  • [Presentation] シンポジウム高齢者の「サルコペニア」ならびに「虚弱」とその対策2012

    • Author(s)
      葛谷 雅文
    • Organizer
      第54回日本老年医学会学術集会
    • Place of Presentation
      東京都千代田区 東京国際フォーラム
    • Year and Date
      2012-06-28

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Published: 2015-06-25  

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