2013 Fiscal Year Final Research Report
Analysis of tissue failure and treatment by iPSCs
| Project/Area Number |
22390144
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Nagoya University |
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Principal Investigator |
ISOBE Ken-ichi 名古屋大学, 医学(系)研究科(研究院), 教授 (20151441)
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| Co-Investigator(Kenkyū-buntansha) |
SHIBATA Rei 名古屋大学, 大学院医学系研究科, 特任講師 (70343689)
MURO Yoshinao 名古屋大学, 大学院医学系研究科, 准教授 (80270990)
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| Project Period (FY) |
2010-04-01 – 2013-03-31
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| Keywords | 老化 / 組織傷害 / iPS細胞 |
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| Research Abstract |
In developed countries, human populations were getting progressively older. Many elderly patients are waiting for curative therapy for intractable diseased such as renal failure, liver cirrhosis and obstructive pulmonary disease. Continued tissue damaging stimuli induce immune cell infiltration to damaged tissue, which progress to tissue fibrosis and finally tissue failure. We analyzed the mechanism of disease progression from tissue damages to chronic inflammation by cellular and molecular level. We found that by continuous stimuli, many innate immune cells migrate to damaged tissue from myeloid-precursors in bone marrow. GADD34 suppressed the myeloid differentiation of hematopoietic progenitor cells. We also succeeded to establish iPSCs from aged mice. We differentiated
aged-iPSCs to tissue cells in vitro and transplanted to model mice such as diabetis.
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[Journal Article] iPS cell sheets created by a novel magnetite tissue engineering method for reparative angiogenesis2013
Author(s)
Kito T, Shibata R, Ishii M, Suzuki H, Himeno T, Kataoka Y, Yamamura Y, Yamamoto T, Nishio N, Ito S, Numaguchi Y, Tanigawa T, Yamashita JK, Ouchi N, Honda H, Isobe K, Murohara T
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Journal Title
Sci Rep
Volume: 3
Pages: 1418
Peer Reviewed
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[Journal Article] Transplantation of neural crest-like cells derived from induced pluripotent stem cells improves diabetic polyneuropathy in mice2013
Author(s)
Okawa T, Kamiya H, Himeno T, Kato J, Seino Y, Fujiya A, Kondo M, Tsunekawa S, Naruse K, Hamada Y, Ozaki N, Cheng Z, Kito T, Suzuki H, Ito S, Oiso Y, Nakamura J, Isobe K
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Journal Title
Cell Transplant
Volume: 22(10)
Pages: 1767-83
Peer Reviewed
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