2012 Fiscal Year Final Research Report
Comprehensive analyses of IL28B genetic factor toward tailor-made therapy for chronic hepatitis C
| Project/Area Number |
22390151
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Nagoya City University |
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Principal Investigator |
TANAKA Yasuhito 名古屋市立大学, 大学院・医学研究科, 教授 (90336694)
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| Co-Investigator(Kenkyū-buntansha) |
SUGAUCHI Fuminaka 名古屋市立大学, 大学院・医学研究科, 研究員 (20405161)
KONDO Yutaka 愛知県がんセンター, 分子腫瘍学部, 室長 (00419897)
MIYOSHI Ichiro 名古屋市立大学, 大学院・医学研究科, 教授 (10183972)
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| Co-Investigator(Renkei-kenkyūsha) |
FUJITA Takashi 京都大学, ウイルス研究所, 教授 (10156870)
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| Project Period (FY) |
2010 – 2012
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| Keywords | HCV / テーラーメイド治療 / IL28B / SNP / IFN ラムダ |
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| Research Abstract |
(Aim) Toward the tailor-made therapy for chronic hepatitis C, basic and clinical researches of IL28B were conducted. (Methods and Results) Clinical research:
(1) Detection of new candidate SNPs
(2) Successful tailor-made therapy based on IL28B and ITPA SNPs. Basic research:
(1) IL28B gene expression was controlled by SNPs and the epigenetic changes within promoter region
(2) Functional analyses of IL28B showed that the induction of IFN-λs followed by immune response might contribute to different viral kinetics and treatment outcome in HCV-infected patients.
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