2012 Fiscal Year Final Research Report
Mechanisms of liver carcinogenesis through phospho-Smad by gene-targeted mice
| Project/Area Number |
22390153
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OKAZAKI Kazuichi 関西医科大学, 医学部, 教授 (70145126)
SEKI Toshihito 関西医科大学, 医学部, 教授 (70163087)
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| Project Period (FY) |
2010 – 2012
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| Keywords | TGF-β / Smad / Liver fibrosis / Carcinogenesis |
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| Research Abstract |
During progression of chronic liver diseases, chronic inflammation together with somatic mutations shifts hepatocytic phospho-Smad signaling from tumor-suppression to fibro-carcinogenesis, accelerating liver fibrosis and increasing risk of liver cancer. Patients with mild fibrosis respond effectively to therapy by successfully switching Smad phospho-isoform signaling from fibro-carcinogenesis to tumor-suppression, while other therapy responders with advanced liver fibrosis do not (Cytokine & Growth Factor Review in press; Hepatology Research Epub ahead of print).
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