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2012 Fiscal Year Final Research Report

the development of novel therapeutic arteriogenesis by nanoparticle-mediated endothelial cell selective delivery system

Research Project

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Project/Area Number 22390160
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionKyushu University

Principal Investigator

EGASHIRA Kensuke  九州大学, 医学研究院, 教授 (60260379)

Project Period (FY) 2010 – 2012
Keywords分子血管病態学 / ナノテクノロジー / DDS / 治療的血管新生
Research Abstract

Currently, there is no effective medicinal therapy for severe ischemic diseases such as critical limb ischemia (CLI). We hypothesized that nanoparticle (NP)-mediated cell-selective delivery of statins to vascular endothelium would more effectively and int

  • Research Products

    (27 results)

All 2013 2012 2011 2010 Other

All Journal Article (8 results) Presentation (16 results) Book (1 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] ナノ粒子DDSを用 いた血管新生治療法の開発2013

    • Author(s)
      的場哲哉、江頭健輔
    • Journal Title

      Bio Clinica北隆館

      Volume: 28(5) Pages: 35-39

  • [Journal Article] Nanoparticle-Mediated Delivery of Pioglitazone Enhances Therapeutic Neovascularization in a Murine Model of Hindlimb Ischemia.2012

    • Author(s)
      Nagahama R, Egashira K ,他
    • Journal Title

      Arteri oscl er Thromb Vasc Biol.

      Volume: 32(10) Pages: 2427-2434

    • DOI

      DOI:10.1161/ATVBAHA.112.253823

  • [Journal Article] anoparticle-Mediated Delivery of Pitavastatin Into Lungs Ameliorates the Development and Induces Regression of Monocrotaline-Induced Pulmonary Artery Hypertension2011

    • Author(s)
      Chen L, Egashira K , 他9名
    • Journal Title

      Hypertension.

      Volume: 57 (2) Pages: 343-350

  • [Journal Article] Imatinib Mesylate-Incorporated Nanoparticle-Eluting Stent Attenuates In-Stent Neointimal Formation in Porcine Coronary Arteries.2011

    • Author(s)
      Masuda S, Egashira K , 他9名
    • Journal Title

      J Atheroscler Thromb.

      Volume: 18 (12) Pages: 1043-1053

  • [Journal Article] 「血管内皮細胞選択的ナノDDS技術」を活用した低侵襲ナノ医療の開発2011

    • Author(s)
      中野覚、江頭健輔
    • Journal Title

      臨床評価臨床評価刊行会

      Volume: 39(2) Pages: 300-304

  • [Journal Article] Nanoparticle-Mediated Endothelial Cell-Selective Delivery of Pitavastatin Induces Functional Collateral Arteries (Therapeutic Arteriogenesis) in a Rabbit Model of Chronic Hindlimb Ischemia.2010

    • Author(s)
      Oda S, Egashira K ,(他6名)
    • Journal Title

      J Vase Surg

      Volume: 52(2) Pages: 412-420

  • [Journal Article] 総説ナノテクノロジーの循環器疾患への応用2010

    • Author(s)
      中野覚、江頭健輔
    • Journal Title

      呼吸と循環医学書院

      Volume: 58(5) Pages: 495-501

  • [Journal Article] 血管医学から先端医療研究開発への展開2010

    • Author(s)
      江頭健輔
    • Journal Title

      血管医学メディカルレビュー社

      Volume: 11(3) Pages: 55(227)-62(234)

  • [Presentation] ナノテクノロジーを用いたdrugdelivery system(ナノDDS)による心血管病に対する革新的治療実用化、2012

    • Author(s)
      江頭健輔
    • Organizer
      第32回日本川崎病学会・学術集会(招待講演)
    • Place of Presentation
      品川インターシティホール
    • Year and Date
      2012-10-13
  • [Presentation] Nanotechnology-Based DDS for Patients with Critical Limb Ischemia2012

    • Author(s)
      Egashira K
    • Organizer
      The 2012 Annual Scientific Meeting of Taiwan Society of Lipids and Atherosclerosis (14)
    • Place of Presentation
      台北市福華國際文教會館、台湾
    • Year and Date
      2012-09-23
  • [Presentation] ナノテクノロジーを基盤とする動脈硬化プラーク破綻と虚血-再灌流傷害に対する新しい治療法の開発、2012

    • Author(s)
      江頭健輔
    • Organizer
      第44回日本動脈硬化学会総会・学術集会(招待講演)
    • Place of Presentation
      ヒルトン福岡シーホーク
    • Year and Date
      2012-07-20
  • [Presentation] Nanoparticle-mediated delivery of pitavastatin via pulse infusion drug delivery catheter attenuates neointima formation after balloon injury in porcine coronary arteries2012

    • Author(s)
      Egashira K
    • Organizer
      The 4th Oriental Congress of Cardiology & The 5th AICT (MTAM,)
    • Place of Presentation
      上海国際会議中心、中国
    • Year and Date
      2012-05-26
  • [Presentation] Impact of nanotechnology-based endothelial cell-selective delivery of pitavastatin for therapeutic angiogenesis in critical limbischemia2012

    • Author(s)
      Egashira K
    • Organizer
      XVIInternationalSymposiumonAtherosclerosis
    • Place of Presentation
      SydneyConventionandExhibitionCentre、オーストラリア
    • Year and Date
      2012-03-28
  • [Presentation] 血管内皮細胞選択的ナノDDS技術を活用した重症虚血性疾患に対する革新的低侵襲ナノ医療2012

    • Author(s)
      江頭健輔
    • Organizer
      重症下肢虚血治療検討会
    • Place of Presentation
      グランド・ハイアット・福岡
    • Year and Date
      2012-03-10
  • [Presentation] 「ナノテクノロジー」を基盤 とする新しいPCIデバイス、治療的血管 新生と心筋梗塞治療一日本初の独創的医 療機器・医薬品の開発を目指して一2012

    • Author(s)
      江頭健輔
    • Organizer
      第2回 Strategy and Treatment For Cardiovascular Disease
    • Place of Presentation
      倉敷国際ホテル
    • Year and Date
      2012-02-25
  • [Presentation] Nanotechnology-based endothelial cell selective DDS for therapeutic neovascularization2011

    • Author(s)
      Egashira K
    • Organizer
      The Second Pacific Symposium on Vascular Biology (Invited lecture)
    • Place of Presentation
      THE SHILLA JEJU, 韓国
    • Year and Date
      2011-11-01
  • [Presentation] ナノテクノロジーを基盤とする新しい治療的血管新生療法と心筋保護-日本初の独創的なナノ治療の実用化を目指して-2011

    • Author(s)
      江頭健輔
    • Organizer
      The12th Vascularand Brain Conference21世紀における血管病治療の新展開
    • Place of Presentation
      帝国ホテル大阪
    • Year and Date
      2011-09-30
  • [Presentation] A New Therapeutic Modality for Ischemia-Reperfusion Injury: Nanoparticle-Mediated Delivery of Pitavastatin into Reperfused Myocardium Reduced Ischemia/Reperfusion Injury in Rats2011

    • Author(s)
      Egashira K
    • Organizer
      The Annual Scientific Meeting of Taiwan Society of Lipids and Atherosclerosis 2011 and The llth Taipei International Vascular Biology Symposium
    • Place of Presentation
      振興醫療財團法人振興醫院第二醫療大樓5樓、台湾
    • Year and Date
      2011-09-18
  • [Presentation] Impact of nanotechnology-based endothelial cell-selective delivery of pitavastatin for therapeutic arteriogenesis in critical limb ischemia2011

    • Author(s)
      Egashira K
    • Organizer
      The 9th Japan-Korea Joint Symposium on Vascular Biology (Symposium)
    • Place of Presentation
      The Westin Chosun Busan, Q
    • Year and Date
      2011-08-25
  • [Presentation] New evidences: Phase IV trials and ongoiog & future studies with pitavastatin2011

    • Author(s)
      Egashira K
    • Organizer
      New evidences: Phase IV trials and ongoiog & future studies with pitavastatin (Invited lecture)
    • Place of Presentation
      CCIB- CENTRO DE CONVENCIONES INTERNACIONALES DE BARCELONA, . -(スペイン)
    • Year and Date
      2011-05-13
  • [Presentation] lmpact of Nanotechnology-based Drag Delivery on Treatment of Cardiovascular Disease2010

    • Author(s)
      Egashira K
    • Organizer
      The Annual Scientific Meeting of Taiwan Society of Lipids and Atherosclerosis 2010 and The 10th Taipei International Vascular Biology Symposium
    • Place of Presentation
      振興醫療 財團法人振興醫院第二醫療大樓6樓國際 會議廳、台湾
    • Year and Date
      2010-08-15
  • [Presentation] A new treatment for CAD: Nanotechnology-based Arteriogenesis and Angiogenesis2010

    • Author(s)
      Egashira K
    • Organizer
      The 4th Oriental Congress of Cardiology & The 5th AICT
    • Place of Presentation
      上海国際会議中心、中国
    • Year and Date
      2010-05-30
  • [Presentation] 血管内皮細胞選択的ナノDDS技術」を基盤とする革新的低侵襲治療的血管新生療法の実現のための橋渡し研究2010

    • Author(s)
      江頭健輔
    • Organizer
      第32回ヒューマンサイエンスバイオインターフェースー創薬のための知的相互交流一
    • Place of Presentation
      全理連ビル
    • Year and Date
      2010-05-19
  • [Presentation] Impact of nanotechnology-based selective delivery of pitavastatin for the development of innovative treatment of ischemic cardiovascular diseases2010

    • Author(s)
      Egashira K
    • Organizer
      7th Metabolic Syndrome, Type II Diabetes and Atherosclerosis Congress
    • Place of Presentation
      La Salle desAmbassadeurs、モロッコ
    • Year and Date
      2010-05-14
  • [Book] ナノテクノロジー血管生物医学事典2011

    • Author(s)
      江頭健輔、的場哲哉
    • Total Pages
      435-436
    • Publisher
      血管生物医学会
  • [Remarks]

    • URL

      http://www.med.kyushu-u.ac.jp/cardiol/1_sentaniryo/

  • [Patent(Industrial Property Rights)] スタチン封入ナノ粒子含有医薬組成物2011

    • Inventor(s)
      江頭健輔
    • Industrial Property Rights Holder
      江頭健輔、九州大学
    • Industrial Property Number
      第4881385号
    • Acquisition Date
      2011-12-09

URL: 

Published: 2014-08-29  

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