2013 Fiscal Year Final Research Report
Development of new therapies and significance of adrenomedullin and mast cells in the abdominal aortic aneurysm.
| Project/Area Number |
22390161
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TSURUDA Toshihiro 宮崎大学, 医学系研究科, 講師 (10389570)
KATO Johji 宮崎大学, フロンティア科学実験総合センター, 教授 (20274780)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | アドレノメデュリン / 腹部大動脈瘤 / マスト細胞 |
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| Research Abstract |
Abdominal aortic aneurysm (AAA) develops based on advanced atherosclerosis; however, the underlying pathogenesis remains unknown. Adrenomedullin (AM) is widely expressed in various organs and tissues, and has anti-inflammatory, anti-oxidant and angiogenic activity. We have reported that AM is produced in mast cells of human AAA and that AM exhibited the anti-fibrotic activity on fibroblasts. We investigated the role of AM in the development of AAA in 12 weeks-old male apoE-/- mice bred with AM heterozygous, or its role when recombinant human (rh)AM was administrated to the apoE-/- male mice, which was infused with 1000ng/kg/min of angiotensin II for 28 days. Mortality tended to be higher in rhAM at 3000ng/kg/hr. Both the incidence and the size of AAA were not significant between the groups. Because of dual nature of AM action on progression or protection of AAA, we may not have observed the biological actions of AM in the development of AAA.
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[Journal Article] Inhibition of development of abdominal aortic aneurysm by glycolysis restriction2012
Author(s)
Tsuruda T, Hatakeyama K, Nagamachi S, Sekita Y, Sakamoto S, Endo GJ, Nishimura M, Matsuyama M, Yoshimura K, Sato Y, Onitsuka T, Imamura T, Asada Y, Kitamura K
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Journal Title
Arterioscler Thromb Vasc Biol
Volume: 32
Pages: 1410-1417
Peer Reviewed
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[Presentation] Angiotensin II-dependent osteoprotegerin production in murine and human heart2012
Author(s)
Tsuruda T, Imamura T, Masuyama H, Sekita Y, Koyama S, Ideguchi T, Kawagoe J, Onitsuka H,Ishikawa T, Date H, Hatakeyama K, Asada Y, Kitamura K
Organizer
European Society of Cardiology Congress 2012
Place of Presentation
Munch,Germany
Year and Date
20120825-29
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