2012 Fiscal Year Final Research Report
Pathogenesis and control of circulating fibrocytes and miRNAs causing interstitial/airway fibrosis and initiating/promoting cancer in the lung
| Project/Area Number |
22390164
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
EBINA Masahito 東北大学, 大学院・医学系研究科, 准教授 (10280885)
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| Co-Investigator(Kenkyū-buntansha) |
KONDOH Takahshi 東北大学, 加齢医学研究所, 教授 (10195901)
OKOUCHI Shinya 東北大学, 病院, 助教 (40375035)
SATO Yasufumi 東北大学, 加齢医学研究所, 教授 (50178779)
INOUE Akira 東北大学, 病院, 特任准教授 (70361087)
TAMADA Tsutomu 東北大学, 病院, 助教 (80396473)
HISATA Shu 東北大学, 病院, 助教 (60466571)
OHTA Hiromitsu 東北大学, 大学院・医学系研究科, 助教 (40451562)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 非閉塞性肺疾患 / 肺線維症 / 呼吸器感染症 / Fibrocyte |
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| Research Abstract |
Although the circulating fibrocytes in the patients with progressive fibrosis have been supposed to cause progressive fibrosis, these cells obtained from patients with various stages of IPF became too differentiated to reveal the sensitivity or tolerance to drugs. Therefore, we examined the circulating micro-RNAs (miRNAs) which might effect on circulating fibrocytes in these severe patients. We compared the expression patterns of miRNAs on Days 0, 7, and 21 in the serum and lung tissues. We found miR-30d increased the most toward Day 21, followed by miR-122,-690, 1907, and 3096b-5p, none of which were increased in the lung tissues. Only miR-322 and miR-874 were moderately increased in both serum and lung tissues. These results suggested these circulating miRNAs as possible biomarkers for pulmonary fibrosis.
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