2012 Fiscal Year Final Research Report
Investigation on host defense mechanism and search for new therapeutic targets against prion diseases
| Project/Area Number |
22390172
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Tohoku University |
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Principal Investigator |
DOH-URA Katsumi 東北大学, 大学院・医学系研究科, 教授 (00263012)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 神経病態免疫学 |
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| Research Abstract |
To reveal the host defense mechanism against prion diseases, host factors induced by the administration of a long-acting prophylactic compound were analyzed, using the technology of genomics and proteomics. Consequently, several specifically induced cytokines or chemokines were identified. Following the evaluation of their therapeutic or prophylactic effects in prion-infected cells or animals, new therapeutic targets related to such immunological factors were selected. Besides, by the analysis of animal strain differencein the compound activity, involvement of thymus cells in the prophylactic effects was suggested.
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[Journal Article] In vivo detection of prion amyloid plaques using [(11)C]BF-227 PET2010
Author(s)
Okamura N, Shiga Y, Furumoto S, Tashiro M, Tsuboi Y, Furukawa K, Yanai K, Iwata R, Arai H, Kudo Y, Itoyama Y, Doh-ura K.
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Journal Title
Eur J Nucl Med Mol Imaging
Volume: 37 (5)
Pages: 934-941
DOI
Peer Reviewed
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