2013 Fiscal Year Final Research Report
Molecular pathogenesis of cerebral small vessel disease.
| Project/Area Number |
22390174
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SATO Toshiya 新潟大学, 脳研究所, 助教 (90359703)
NOZAKI Hiroaki 新潟大学, 医学部, 助教 (20547567)
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| Project Period (FY) |
2010-04-01 – 2013-03-31
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| Keywords | CARASIL / 血液脳関門 / 脳小血管 / HTRA1 / 平滑筋細胞 / 周皮細胞 / 血管性認知症 |
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| Research Abstract |
Cerebral small-vessel disease is a common disorder in elderly populations; however, its molecular basis is not well understood. We recently demonstrated that mutations in the high-temperature requirement A (HTRA) serine peptidase 1 (HTRA1) gene cause a hereditary cerebral small-vessel disease, cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL). HTRA1 belongs to the HTRA protein family, whose members have dual activities as chaperones and serine proteases and also repress transforming growth factor-beta (TGF-beta) family signaling. We investigated the molecular pathogenesis of CARASIL in HTRA1 null mouse. By immunohistochemical analysis we have found the alteration in cerebral small vessels in the model. This model mouse could be useful for the investigation of the pathogenesis of cerebral small vessel disease.
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[Journal Article] A novel mutation in the HTRA1 gene causes CARASIL without alopecia2011
Author(s)
Nishimoto Y, Shibata M, Nihonmatsu M, Nozaki H, Shiga A, Shirata A, Yamane K, Kosakai A, Takahashi K, Nishizawa M, Onodera O, Suzuki N
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Journal Title
Neurology
Volume: 76(15)
Pages: 1353-5
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[Journal Article] Cerebral small-vessel disease protein HTRA1 controls the amount of TGF-β1 via cleavage of proTGF-β12011
Author(s)
Shiga A, Nozaki H, Yokoseki A, Nihonmatsu M, Kawata H, Kato T, Koyama A, Arima. K, Ikeda M, Katada S, Toyoshima Y, Takahashi H, Tanaka A, Nakano I, Ikeuchi T, Nishizawa M, Onodera O
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Journal Title
Hum Mol Genet
Volume: 20(9)
Pages: 1800-10
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