2012 Fiscal Year Final Research Report
Development of molecular targeted therapy of multiple sclerosis on the basis of membrane protein microarray analysis and gene interactions
| Project/Area Number |
22390178
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Kyushu University |
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Principal Investigator |
KIRA Jun-ichi 九州大学, 医学研究院, 教授 (40183305)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUSHITA Takuya 九州大学, 医学研究院, 学術研究員 (00533001)
KAWAMURA Nobutoshi 九州大学, 医学研究院, 共同研究員 (00432930)
KAWANO Yuji 九州大学, 大学病院, 講師 (20333479)
YOSHIMURA Satoshi 九州大学, 大学病院, 共同研究員 (20596390)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 多発性硬化症 / 遺伝子間相互作用 / サイトカイン / 自己抗体 |
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| Research Abstract |
In Japanese demyelinating disease, whereas DRB1*0901 is a disease resi stance gene regardless of the disease phenotype, disease susceptibility gene revealed that depending on the disease phenotype. IL7RA gene, a disease susceptibility gene in Western Caucasian, was shown to be a disease susceptibility gene in Japanese MS. The IL2RA gene, may contribute to disease susceptibility only when it interacts with HLA-DRB1*1501 or HLA-DRB1*0405. By using a cell-free protein synthesis system, LUZP1 is obtained as a self-antigen significantly more in CIDP than Balo disease, SOX6 was obtained as a self-antigen significantly more in MS than Balo disease and CIDP. The high sensitivity anti-AQP4 antibody assay revealed that IgG1 is associated with disease duration, and there was a reverse correlation between the spinal cord lesion length IgG2 .
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[Journal Article] Quantitative assays for anti-aquaporin-4 antibody with subclass analysis in neuromyelitis optica2012
Author(s)
Isobe N, Yonekawa T, Matsushita T, Kawano Y, Masaki K, Yoshimura S, Fichna J, Chen S, Furmaniak J, Smith BR, Kira J
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Journal Title
Multiple Sclerosis
Volume: 18
Pages: 1541-1551
DOI
Peer Reviewed
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[Journal Article] Extensive loss of connexins in Balo's disease: evidence for an auto- antibody- independent astrocytopathy via impaired astrocyte-oligodendrocyte/myelin interaction2012
Author(s)
Masaki K, Suzuki SO, Matsushita T, Yonekawa T, Matsuoka T, Isobe N, Motomura K, Wu XM, Tabira T, Iwaki T, Kira J
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Journal Title
Acta Neuropathol
Volume: 123
Pages: 887 -900
DOI
Peer Reviewed
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[Journal Article] Interleukin-7 receptor alpha gene polymorphism influences multiple sclerosis risk in Asians2011
Author(s)
Fang L*, Isobe N*, Yoshimura S, Yonekawa T, Matsushita T, Masaki K, Doi H, Ochi K, Miyamoto K, Kawano Y, Kira J
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Journal Title
Neurology
Volume: 76
Pages: 2125-2127
DOI
Peer Reviewed
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[Journal Article] SNP based analysis of the HLA locus in Japanese multiple sclerosis patients2011
Author(s)
McElroy JP, Isobe N, Gourraud PAFD, Cailler GSJ, Matsushita T, Kohriyama T, Miyamoto K, Nakatsuji Y, Miki T, Hauser SL, Oksenberg JR, Kira J
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Journal Title
Gene Immunity
Volume: 12
Pages: 523-530
DOI
Peer Reviewed
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[Journal Article] Impact and characteristics of quality of life in Japanese patients with multiple sclerosis2011
Author(s)
Kikuchi H, Mifune N, Niino M, Ohbu S, Kira J, Kohriyama T, Ota K, Tanaka M, Ochi H, Nakane S, Maezawa M, Kikuchi S
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Journal Title
Qual Life Res
Volume: 20
Pages: 119-131
DOI
Peer Reviewed
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[Journal Article] Reappraisal of brain MRI features in multiple sclerosis and neuromyelitis optica patients according to anti-aquaporin-4 antibody status2010
Author(s)
Matsushita T, Isobe N, Piao H, Matsuoka T, Ishizu T, Doi H, Masaki K, Yoshimura T, Yamasaki R, Ohyagi Y, Kira J
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Journal Title
J Neurol Sci
Volume: 291
Pages: 37-43
DOI
Peer Reviewed
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