2013 Fiscal Year Final Research Report
Basic reserach for developing a new therapy by transplantation of mesenchymal stem cells against neurodegenerative diseases
| Project/Area Number |
22390180
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HONMOU Osamu 札幌医科大学, 医学部, 教授 (90285007)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | パーキンソン病 / 骨髄間葉系細胞 / 移植 / 治療 / 神経変性疾患 / 再生 / 血液脳関門 |
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| Research Abstract |
To explore a novel therapy against Parkinson disease, we evaluated the therapeutic effects of human bone marrow-derived mesenchymal stem cells (hBM-MSCs) in 6-OHDA induced Parkinson disease model rats. Intravenous administration of hBM-MSCs inhibited methamphetamine-stimulated rotational behevior at 7, 14, 21 and 28 days after transplantation. Rats injected with hBM-MSCs displayed significant preservation of tyrosine hydroxylase (TH)-positive fibers in the striatum and the number of TH-positive neurons in the substantia nigra compacta (SNpc). In contrast, the immunoreactivity of ionized calcium binding adaptor molecule 1 (Iba1) was markedly inhibited by intravenous admnistration of hBM-MSCs. The findings that hBM-MSCs attenuate 6-OHDA-induced dopaminergic neurodegeneration and glial activation raise the possibility that hBM-MSCs could be a novel therapeutic option to prevent Parkinson disease development.
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