2012 Fiscal Year Final Research Report
Treatment of neurological disorders by quadripulse stimulation (QPS): basic mechanisms and clinical trials
| Project/Area Number |
22390181
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
UGAWA Yoshikazu 福島県立医科大学, 医学部神経内科学講座, 教授 (50168671)
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| Co-Investigator(Renkei-kenkyūsha) |
HANAJIMA Ritsuko 東京大学, 医学部付属病院, 助教 (80396738)
TERAO Yasuo 東京大学, 医学部付属病院, 講師 (20343139)
ENOMOTO Hiroyuki 福島県立医科大学, 医学部, 講師 (60528107)
MOCHIZUKI Hitoshi 宮崎大学, 医学部, 講師 (50501699)
ENOMOTO Setsu 福島県立医科大学, 医学部, 講師 (80396374)
YABE Hirooki 福島県立医科大学, 医学部, 教授 (60210316)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 磁気刺激 / シナプス可塑性 / 反復磁気刺激 / BDNF / パーキンソン病 |
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| Research Abstract |
The neuronal adaptation or new information acquisition of human brain, such as studies in sports or schools, is known to be produced by synaptic plasticity in our brain. We developed a new transcranial magnetic stimulation method to induce such synaptic plasticity, long-term potentiation or depression (LTP/LTD), in the human brain (quadripulse stimulation (QPS)). In these three years, we have confirmed the safety of QPS and shown that the plasticity is able to be induced in the sensory cortex in addition to the motor cortex. The metabolic changes in the brain after QPS have been studied by functional MRI and also near infrared spectroscopy (NIRS). We showed that the QPS effect was not affected by BDNF polymorphism, which is superior to other stimulation methods affected by BDNF polymorphism. We have alsoreported a clinical efficacy of rTMS on motor symptoms in patients with Parkinson’s disease.
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[Journal Article] Cortical hemoglobin concentration changes underneath the coil after single-pulse transcranial magnetic stimulation: A near-infrared spectroscopy (NIRS) study2013
Author(s)
Furubayashi T, Mochizuki H, Terao Y, Arai N, Hanajima R, Hamada M, Matsumoto H, Nakatani-Enomoto S, Okabe S, Yugeta A, Inomata-Terada S, Ugawa Y
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Journal Title
J Neurophysiol
Volume: 109
Pages: 1626-1673
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[Journal Article] Bidirectional modulation of sensory cortical excitability by quadripulse magnetic stimulation (QPS) in humans2012
Author(s)
Nakatani-Enomoto S, Hanajima R, Hamada M, Terao Y, Matusmoto H, Shirota Y, Okabe S, Hirose M, Nakamura K, Fusubayashi T, Kobayashi S, Mochizuki H, Enomoto H, Ugawa Y.
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Journal Title
Clin Neurophysiol
Volume: 123
Pages: 1415-1421
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[Journal Article] Quadri-pulse stimulation (QPS) induced LTP/LTD was not affected by Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene2011
Author(s)
Nakamura K, Enomoto H, Hanajima R, Hamada M, Shimizu E, Kawamura Y, Sasaki T, Matsuzawa D, Sutoh C, Shirota Y, Terao Y, Ugawa Y.
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Journal Title
Neurosci Letts
Volume: 487
Pages: 264-267
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[Journal Article] Some evidence supporting the safety of quadri-pulse stimulation (QPS)2011
Author(s)
Nakatani-Enomoto S, Hanajima R, Hamada M, Mochizuki H, Kobayashi S, Enomoto H,Sugiura Y, Matsumoto H, Furubayashi T, Terao Y, Sato F, Ugawa Y.
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Journal Title
Brain Stimulation
Volume: 4
Pages: 303-305
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[Journal Article] Bidirectional effects on inter-hemispheric resting-state functional connectivity induced by excitatory and inhibitory repetitive transcranial magnetic stimulation
Author(s)
WatanabeT, Hanajima R, Shirota Y, Ohminami S, Tsutsumi R, Terao Y, Ugawa Y, Hirose S, Miyashita Y, Konishi S, Kunimatsu A, Ohtomo K
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Journal Title
Human Brain Mapping (in press)
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