2012 Fiscal Year Final Research Report
Research on the association of GIP and metabolic diseases
| Project/Area Number |
22390183
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Akita University |
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Principal Investigator |
YAMADA Yuichiro 秋田大学, 大学院・医学系研究科, 教授 (60283610)
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| Co-Investigator(Kenkyū-buntansha) |
FUJITA Hiroki 秋田大学, 医学部, 講師 (30333933)
TSUKIYAMA Katushi 秋田大学, 医学部, 准教授 (10359797)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 糖尿病 / 栄養学 / 生理活性 / インクレチン |
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| Research Abstract |
GIP is one of the gut hormones, which stimulate insulin secretion from pancreatic β-cells after meal ingestion as an incretin. GIP receptor is expressed in various tissues, in addition to pancreaticβ-cells, and GIP is expected to play a several physiological role in vivo. We have shown that GIP receptor is expressed in stromal vascular fraction cells, in addition to adipocytes and that GIP regulates function of adipose tissues. GLP-1, the other incretin, has its proper function and α-glucosidase inhibitor can modulate the function of incretin through modulating the carbohydrate absorption from the gut.
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[Journal Article] SOD1, but not SOD3, deficiency accelerates diabetic renal injury in C57BL/6-Ins2(Akita) diabetic mice2012
Author(s)
Fujita H, Fujishima H, Takahashi K, Sato T, Shimizu T, Morii T, Shimizu T, Shirasawa T, Qi Z, Breyer MD, Harris RC, Yamada Y, Takahashi T
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Journal Title
Metabolism
Volume: 61(12)
Pages: 1714-1724
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[Journal Article] Efficacy and safety of patient-directed titration of once-daily pre-dinner premixed biphasic insulin aspart 70/30 injection in Japanese type 2 diabetic patients with oral antidiabetic drug failure: STEP-AKITA study2011
Author(s)
Narita T, Goto T, Suganuma Y, Hosoba M, Morii T, Sato T, Fujita H, Miura T, Shimotomai T, Yamada Y, Kakei M
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Journal Title
J Diabetes Invest
Volume: 2(1)
Pages: 63-70
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