2012 Fiscal Year Final Research Report
Elucidation of molecular mechanism on thyroid carcinogenesis anddevelopmental application of molecular targeting therapy
| Project/Area Number |
22390189
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Keiji 長崎大学, 大学院・医歯薬学総合研究科, 准教授 (00196809)
MITSUTAKE Norisato 長崎大学, 大学院・医歯薬学総合研究科, 助教 (50404215)
SAENKO Vladimir 長崎大学, 大学院・医歯薬学総合研究科, 准教授 (30343346)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 内分泌学 / 甲状腺がん / 遺伝子多型解析 / 細胞機能解析 / がん基礎研究 |
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| Research Abstract |
We have successfully established a cell culture system from primary human thyroid tissues and identified the multi-potential stem cell-like cells in a specific serum-free medium condition. One speculates that there is a profound relationship of reprogramming and mesenchymal transition between stem cell-like cells and differentiated cells from thyroid tissues. These findings may suggest a new aspect and relationship of thyroid cancer stem cells during its carcinogenesis. Furthermore we have studied the functional role of FOXE1 that is a major thyroid cancer-associated SNP gene. Using immunohistochemistry, specific patterns of FOXE1 expression in thyroid carcinomas have been identified. We have separately clarified a strong association between the SNPs of FOXE1 and NKX-2, and the Japanese thyroid cancer cases. This is the first report on the different ethnics besides Caucasians. Finally we found the new evidence of imanitib, a molecular targeting agent, selectively inhibited an increase of NFkappa B activity induced by irradiation in cultured thyroid cancer cell lines. The combination chemotherapy with radiation may become more efficient therapeutic approach for a poor-prognosis thyroid anaplastic cancer patient clinically.
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[Journal Article] Unilateral follicular variant of papillary thyroid carcinoma with unique KRAS mutation in struma ovarii in bilateral ovarian teratoma: a rare case report2012
Author(s)
Stanojevic B, Dzodic R, Saenko V, Milovanovic Z, Krstevski V, Radlovic P, Buta M, Rulic B, Todorovic L, Dimitrijevic B, Yamashita S
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Journal Title
BMC Cancer
Volume: 12(1)
Pages: 224
DOI
Peer Reviewed
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[Journal Article] Dedifferentiation of human primary thyrocytes into multilineage progenitor cells without gene introduction2011
Author(s)
Suzuki K, Mitsutake N, Saenko V, Suzuki M, Matsuse M, Ohtsuru A, Kumagai A, Uga T, Yano H, Nagayama Y, Yamashita S
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Journal Title
PLoS One
Volume: 6(4)
Pages: e19354
DOI
Peer Reviewed
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[Journal Article] miR-195, miR-455-3p and miR-10a(*)are implicated in acquired temozolomide resistance in glioblastoma multiforme cells2010
Author(s)
Ujifuku K, Mitsutake N, Takakura S, Matsuse M, Saenko V, Suzuki K, Hayashi K, Matsuo T, Kamada K, Nagata I, Yamashita S
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Journal Title
Cancer Lett
Volume: 296(2)
Pages: 241-248
DOI
Peer Reviewed
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