2012 Fiscal Year Final Research Report
Basic research aimed at understanding and overcoming of the primary and secondary resistance in molecular target therapy
Project/Area Number |
22390192
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Hematology
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Research Institution | Nagoya University |
Principal Investigator |
NAOE Tomoki 名古屋大学, 医学系研究科, 教授 (50217634)
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Co-Investigator(Kenkyū-buntansha) |
TOMITA Akihiro 名古屋大学, 医学部附属病院, 講師 (80378215)
MINAMI Yousuke 名古屋大学, 医学(系)研究科(研究院), COE 特任講師 (60513752)
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Project Period (FY) |
2010 – 2012
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Keywords | 分子標的治療 / 残存 / 耐性 / がん薬物治療 / キナーゼ阻害剤 |
Research Abstract |
Although the outcome of patients with hematopoietic malignancies is significantly improved by using molecular target therapies, residual tumors and/or acquired resistance have become contemporary issues in the clinical field. In this study
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Research Products
(25 results)
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[Journal Article] Retention of CD34(+) CML stem/progenitor cells during imatinib treatment and rapid decline after treatment with second-generation BCR-ABL inhibitors.2012
Author(s)
Minami Y, Abe A, Minami M, Kitamura K, Hiraga J, Mizuno S, Ymamoto K, Sawa M, Inagaki Y, Miyamura K, Naoe T
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Journal Title
Leukemia
Volume: 26
Pages: 2142-2143
Peer Reviewed
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[Journal Article] The mTOR inhibitor, everolimus (RAD001), overcomes resistanceto imatinib in quiescent Ph-positive acute lymphoblastic leukemia cells2011
Author(s)
Kuwatsuka Y, Minami M, Minami Y, Sugimoto K, Hayakawa F, Miyata Y, Abe A, Goff DJ, Kiyoi H, Naoe T.
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Journal Title
Blood Cancer J
Volume: 1(5)
Pages: e17
Peer Reviewed
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[Journal Article] Japan Adult Leukemia Study Group. BCR-ABL1 mutations in patients with imatinib-resistant Philadelphia chromosome-positive leukemia by use of the PCR-Invader assay.2011
Author(s)
Ono T, Miyawaki S, Kimura F, Kanamori H, Ohtake S, Kitamura K, Fujita H, Sugiura I, Usuki K, Emi N, Tamaki S, Aoyama Y, Kaya H, Naoe T, Tadokoro K, Yamaguchi T, Ohno R, Ohnishi K
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Journal Title
Leuk Res
Volume: 35
Pages: 598-603
Peer Reviewed
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[Journal Article] Trough plasma concentration of imatinib reflects BCR-ABL kinase inhibitory activity and clinical response in chronic-phase chronic myeloid leukemia: a report from the BINGO study.2010
Author(s)
Ishikawa Y, Kiyoi H, Watanabe K, Miyamura K, Nakano Y, Kitamura K, Kohno A, Sugiura I, Yokozawa T, Hanamura A, Yamamoto K, Iida H, Emi N, Suzuki R, Ohnishi K, Naoe T.
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Journal Title
Cancer Sci
Volume: 101
Pages: 2186-2192
Peer Reviewed
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