2012 Fiscal Year Final Research Report

Investigation of change in HIV-1 replication capacityover the epidemic

Research Project

Project/Area Number	22390203
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Research Field	Infectious disease medicine
Research Institution	Nagasaki University (2011-2012) The University of Tokyo (2010)
Principal Investigator	MIURA Toshiyuki 長崎大学, 熱帯医学研究所, 客員教授 (00296576)
Co-Investigator(Kenkyū-buntansha)	TACHIKAWA Ai 東京大学, 医科学研究所, 准教授 (10396880) HOSOYA Noriaki 東京大学, 医科学研究所, 特任助教 (30568928) ARIYOSHI Koya 長崎大学, 熱帯学研究所, 教授 (30311400)
Project Period (FY)	2010 – 2012
Keywords	感染症防御学
Research Abstract	Human Immunodeficiency Virus typeI (HIV-1) is evolving rapidly due to various selection pressures and its error-prone reverse-transcriptase.Temporal change in replication capacity of HIV-1 at a population level was examined. It was found that in vitro HIV-1 replication capacity associated with Gag-Protease has been declined in Japan. This result will provide significant insight to the research community with regard to the direction of HIV evolution.

(2 results)