2012 Fiscal Year Final Research Report
The development of conditionally replicating adenovirus targeting cancer stem cell for innovative treatment for pediatric cancer
| Project/Area Number |
22390210
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kagoshima University |
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Principal Investigator |
KOSAI Kenichiro 鹿児島大学, 大学院・医歯学総合研究科, 教授 (90258418)
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| Co-Investigator(Kenkyū-buntansha) |
MITSUI Kaoru 鹿児島大学, 大学院・医歯学総合研究科, 講師 (40324975)
IRIE Rie 鹿児島大学, 大学院・医歯学総合研究科, 助教 (90381178)
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| Co-Investigator(Renkei-kenkyūsha) |
KONDO Toru 北海道大学, 遺伝子病制御研究所, 教授 (30270573)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 小児腫瘍 / 遺伝子治療 / がん幹細胞 / アデノウイルスベクター / 増殖型ウイルス |
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| Research Abstract |
Although pediatric carcinomas have differentclinical and biological features from those of adult carcinomas, gene therapy for pediatric carcinoma has not been well developed. The present study aims to develop m-CRAs (conditionally replicating adenovirus targeting with multiple tumor-specific factors) that specifically treat cancer stem cells, leading to innovative therapy against pediatric carcinoma.
First, we have established the methods to enrich and purify cancer stem cells in soft tissue sarcoma, giloblastoma, hepatoblastoma et al.
Second, we revealed that our original m-CRAs efficiently treat cancer stem cells in such pediatric carcinoma.
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Research Products
(28 results)
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[Journal Article] Anti-Fas Gene Therapy Prevents Doxorubicin-induced Acute Cardiotoxicity through Mechanisms Independent of Apoptosis2010
Author(s)
Miyata S, Takemura G, Kosai K, Takahashi T, Esaki M, Li L, Kanamori H, Maruyama R, Goto K, Tsujimoto A, Takeyama T, Kawaguchi T, Ohno T, Nishigaki K, Fujiwara T, Fujiwara H, Minatoguchi S
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Journal Title
Am J Pathol
Volume: 176(2)
Pages: 687-98
DOI
Peer Reviewed
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