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2012 Fiscal Year Final Research Report

Molecular mechanism of D-serine for pathophysiology of schizophrenia

Research Project

  • PDF
Project/Area Number 22390220
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionChiba University

Principal Investigator

HASHIMOTO Kenji  千葉大学, 社会精神保健教育研究センター, 教授 (10189483)

Co-Investigator(Renkei-kenkyūsha) IYO Masaomi  千葉大学, 大学院・医学研究院, 教授 (50191903)
MORI Hisashi  富山大学, 大学院・医学薬学研究部(医学), 教授 (00239617)
Project Period (FY) 2010 – 2012
Keywords統合失調症 / D型セリン / NMDA受容体 / D型サイクロセリン / セリンラセマーゼ
Research Abstract

D-serine in the brain is known to be synthesized from serine racemase (SRR). In the methamphetamine model of schizophrenia, we found that methamphetamine-induced behavioral sensitization was not detected in the SRR knock-out mice. This study suggests that SRR plays a role in the development of behavioral sensitization by methamphetamine treatment.

  • Research Products

    (11 results)

All 2013 2012 2011 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (4 results) Remarks (1 results)

  • [Journal Article] Glutamate modulators as potential therapeutic drugs in schizophrenia and affective disorders2013

    • Author(s)
      Hashimoto, K., Malchow, B., Falkai, P., and Schmitt, A
    • Journal Title

      Eur. Arch. Psychiatry Clin. Neurosci

      Volume: (in press)

    • DOI

      DOI:10.1007/s00406-013-0399-y.

    • Peer Reviewed
  • [Journal Article] Is D-cycloserine a prodrug forD-serine in the brain? Biol2013

    • Author(s)
      Horio, M., Mori, H., and Hashimoto, K
    • Journal Title

      Psychiatry

      Volume: (in press)

    • DOI

      DOI:10.1016/j.biopsych.2012.07.013

    • Peer Reviewed
  • [Journal Article] Neonatal disruption of serine racemase causes schizophrenia-like behavioral abnormalities in adulthood: Clinical rescue by D-serine2013

    • Author(s)
      Hagiwara, H., Iyo, M., and Hashimoto, K
    • Journal Title

      PLoS One

      Volume: 8 Pages: e62438

    • Peer Reviewed
  • [Journal Article] Decreased levels of D-aspartic acid in the forebrain of serine racemase (Srr) knock-out mice2013

    • Author(s)
      Horio, M., Ishima, T., Fujita, Y., Inoue, R., Mori, H., and Hashimoto, K
    • Journal Title

      Neurochem. Int

      Volume: 62 Pages: 843-847

    • DOI

      DOI:10.1016/j.neuint.2013.02.015.

    • Peer Reviewed
  • [Journal Article] Role of serine racemase in behavioral sensitization in mice after repeated administration of methamphetamine2012

    • Author(s)
      Horio, M., Kohno, M., Fujita, Y., Ishima, T., Inoue, R., Mori, H., and Hashimoto, K
    • Journal Title

      PLoS One

      Volume: 7 Pages: e35494

    • DOI

      DOI:10.1371/journal.pone.0035494.

    • Peer Reviewed
  • [Journal Article] Levels of D-serine in the brain and peripheral organs of serine racemase (Srr) knock-out mice2011

    • Author(s)
      Horio, M., Kohno, M., Fujita, Y., Ishima, T., Inoue, R., Mori, H., and Hashimoto, K
    • Journal Title

      Neurochem. Int

      Volume: 59 Pages: 853-859.

    • DOI

      DOI:10.1016/j.neuint.2011.08.017.

    • Peer Reviewed
  • [Presentation] Therapeutic effects of metabotropic glutamate receptor 5positive allosteric modulator CDPPB on phencyclidine-induced cognitive deficits in mice2012

    • Author(s)
      Hashimoto, K., Horio, M., and Fujita, Y
    • Organizer
      22^<nd> Neuropharmacology Conference "Cognitive Enhancers"
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      20121011-12
  • [Presentation] D-サイクロセリンは、脳においてD-セリンのプロドラッグか?2012

    • Author(s)
      堀尾菜央、森寿、橋本謙二
    • Organizer
      第8回D-アミノ酸研究会学術講演会
    • Place of Presentation
      滋賀県大津市
    • Year and Date
      20120907-08
  • [Presentation] Lack of behavioral sensitization in serine racemase knock-out mice after administration of methamphetamine2011

    • Author(s)
      Horio, M., Fujita, Y., Kohno, M., Inoue, R., Mori, H., and Hashimoto, K
    • Organizer
      The 41th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      20111112-16
  • [Presentation] セリンラセマーゼ遺伝子欠損マウスでの覚せい剤投与による行動感作の欠如2011

    • Author(s)
      堀尾菜央、河野眞美、藤田有子、井上蘭、森寿、橋本謙二
    • Organizer
      第7回D-アミノ酸研究会学術講演会
    • Place of Presentation
      東京都
    • Year and Date
      20110909-10
  • [Remarks]

    • URL

      http://www.m.chiba-u.ac.jp/class/shakai/jp/index.html

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Published: 2014-08-29  

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