Development of cancer diagnosis method based on the quantitative measurement of DNA synthesis rate by means of positron emission tomography.

2012 Fiscal Year Final Research Report

• Project/Area Number: 22390241
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
• Principal Investigator: TOYOHARA Jun 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 専門副部長 (50425659)
• Co-Investigator(Kenkyū-buntansha): KUBOTA Kazuo 独立行政法人国立国際医療研究センター, 放射線科核医学室, 医長 (40161674) ; YAMAMOTO Yuka 香川大学, 医学部付属病院, 講師 (30335872)
• Co-Investigator(Renkei-kenkyūsha): ISHIWATA Kiichi 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター, 研究部長 (50143037) ; ISHII Kenji 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター, 研究部長 (10231135) ; ODA Keiichi 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター, 研究員 (70224235) ; SAKATA Muneyuki 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター, 研究員 (00403329) ; NARIAI Tadashi 東京医科歯科大学, 医学部付属病院, 准教授 (00228090)
• Research Collaborator: ELSINGA Philip University Medical Center Groningen, Faculty of Medical Sciences, Professor ; SCHWARTZ Jeffrey L. University of Washington Medical Center, Department of Radiation Oncology, Associate Professor
• Project Period (FY): 2010 – 2012
• Keywords: 核医学(PETを含む) / 放射性医薬品 / 分析化学 / 放射線 / 核酸 / 癌 / 薬学

Research Abstract

4DST is a newly developed PET tracer that can be used to image DNA synthesis, and its application in clinical settings is being studied at many facilities. 4DST will be applied to more types of cancer. Establishment of the clinical significance is needed.

Research Products

• [Journal Article] Longitudinal observation of ^<11>C-4DST uptake in turpentine-induced inflammatory tissue. (2013)
  • Author(s): Toyohara, J., Sakata, M., Oda, K., Ishii, K. and Ishiwata, K.
  • Journal Title: Nucl. Med. Biol. Volume: 40 Pages: 240-244
  • DOI: doi:10.1016/j.nucmedbio.2012.10.008
  • Peer Reviewed
• [Journal Article] Application of[^<11>C]SA4503 to selection of novel sigmal selective agonists. (2012)
  • Author(s): Toyohara, J., Kobayashi, T., Mita, S. and Ishiwata, K.
  • Journal Title: Nucl. Med. Biol. Volume: 39 Pages: 1117-1121
  • DOI: doi:10.1016/j.nucmedbio.2012.06.004
  • Peer Reviewed
• [Journal Article] Re-evaluation of in vivo selectivity of [^<11>C]SA4503 to sigmal receptors in the brain : contributions of emopamil binding protein. (2012)
  • Author(s): Toyohara, J., Sakata, M. and Ishiwata, K
  • Journal Title: Nucl. Med. Biol. Volume: 39 Pages: 1049-1052
  • DOI: doi:10.1016/j.nucmedbio.2012.03.002
  • Peer Reviewed
• [Journal Article] Roles of sigmal receptors in the mechanisms of action of CNS drugs. (2012)
  • Author(s): Toyohara, J., Sakata, M. and Ishiwata, K.
  • Journal Title: Trans. Neurosci. Volume: 3 Pages: 294-299
  • DOI: doi:10.2478/s13380-012-0030-0
  • Peer Reviewed
• [Journal Article] Evaluation of 4'-[methyl-^<11>C]thiothymidine (^<11>C-4DST) in a rodent tumor and inflammation model. (2012)
  • Author(s): Toyohara, J., Elsinga, P. H., Ishiwata, K., Sijbesma, J. W. A. Dierckx, R. A. J. 0. and van Waarde, A.
  • Journal Title: J. Nucl. Med. Volume: 53 Pages: 488-494
  • DOI: doi:10.2967/jnumed.111.098426
  • Peer Reviewed
• [Journal Article] ^<11>C-4DST PET/CT for proliferation imaging in non-small-cell-lung cancer. (2012)
  • Author(s): Minamimoto, R., Toyohara, J., Seike, A., Ito, H., Endo, H., Mooorka, M., Nakajima, K., Mitsumoto, T., Ito, K., Okasaki, M., Ishiwata, K. and Kubota K.
  • Journal Title: J. Nucl. Med. Volume: 53 Pages: 199-206
  • DOI: DOI:10.2967/jnumed.111.095539
  • Peer Reviewed
• [Journal Article] Animal tumor models for PET in drug development. (2011)
  • Author(s): Toyohara, J. and Ishiwata, K.
  • Journal Title: Ann. Nucl. Med. Volume: 25 Pages: 717-731
  • DOI: doi:10.1007/sl2149-011-0531-x
  • Peer Reviewed
• [Journal Article] Whole-body distribution and brain tumor imaging with ^<11>C-4DST : a pilot study. (2011)
  • Author(s): Toyohara, J., Nariai, T., Sakata, M., Oda, K., Ishii, K., Kawabe, T., Irie, T., Saga, T., Kubota, K. and Ishiwata, K.
  • Journal Title: J. Nucl. Med. Volume: 52 Pages: 1322-1328
  • DOI: doi:10.2967/jnucmed.111.088435
  • Peer Reviewed
• [Presentation] Imaging of DNA synthesis rate of malignant brain tumor with newly developed PET molecular imaging probe ^<11>C-4DST (2013)
  • Author(s): Inaji, M.
  • Organizer: Joint neurosurgical convention 2013 (the 6^<th> international Mt. Bandai symposium for neuroscience and the 7^<th> Pan-pacific neurosurgery congress)
  • Place of Presentation: Hawaii (USA)
  • Year and Date: 20130129-20130203
• [Presentation] FDG以外の腫瘍PETイメージングプローブ (2013)
  • Author(s): 豊原潤
  • Organizer: 第7回四国PET勉強会
  • Place of Presentation: 高松
  • Year and Date: 2013-03-16
• [Presentation] PET薬剤の被曝線量評価における小動物実験とヒト全身PETの比較 (2012)
  • Author(s): 坂田宗之
  • Organizer: 第52回日本核医学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 20121011-20121113
• [Presentation] ^<11>C-4DSTの炎症集積に関する検討 (2012)
  • Author(s): 豊原潤
  • Organizer: 第52回日本核医学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 20121011-20121113
• [Presentation] 新規PET薬剤からfirst-in-human studyまで-多施設共同研究への取り組み- (2012)
  • Author(s): 豊原潤
  • Organizer: 第52回日本核医学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 20121011-20121113
• [Presentation] ^<11>C-4DST PETを用いた悪性脳腫瘍のDNA合成能評価法の検討 (2012)
  • Author(s): 成相直
  • Organizer: 第52回日本核医学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 20121011-20121013
• [Presentation] 多発性骨髄腫のFDG-PET、メチオニンPET、4DST-PETの比較検討 (2012)
  • Author(s): 岡崎百子
  • Organizer: 第52回日本核医学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 20121011-20121013
• [Presentation] DNA合成診断薬剤11C-4DSTによる肺癌リンパ節転移の検出能力に関する検討 (2012)
  • Author(s): 南本亮吾
  • Organizer: 第52回日本核医学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 20121011-2012-1113
• [Presentation] ^<11>C-4DST PETを用いたDNA合成能イメージングによる悪性脳腫瘍診断 (2012)
  • Author(s): 稲次基希
  • Organizer: 第13回日本分子脳神経外科学会、
  • Place of Presentation: 熊本
  • Year and Date: 20120920-20120921
• [Presentation] A molecular imaging study of multiple myeloma : comparison of ^<18>F-FDG, ^<11>C-methionine (MET), and ^<11>C-thiothymidine (4DST) PET. (2012)
  • Author(s): Okasaki, M.
  • Organizer: 59^<th> Annual meeting of the society of nuclear medicine
  • Place of Presentation: Miami (USA)
  • Year and Date: 20120609-20120613
• [Presentation] Proliferation imaging by ^<11>C-4DST PET/CT for differentiation of malignant and benign lesion. (2012)
  • Author(s): Minamimoto, R.
  • Organizer: 59th Annual meeting of the society of nuclear medicine
  • Place of Presentation: Miami (USA)
  • Year and Date: 20120609-20120613
• [Presentation] DNA合成能のPET分子イメージングによる脳腫瘍増殖能の画像診断-新規診断薬剤^<11>C-4DSTの臨床応用- (2012)
  • Author(s): 成相直
  • Organizer: 第35回日本脳神経CI学会
  • Place of Presentation: 横浜
  • Year and Date: 20120302-20120303
• [Presentation] DNA合成の分子イメージング-4DST研究の現状と展望- (2012)
  • Author(s): 豊原潤
  • Organizer: 第77回日本核医学会関東甲信越地方会
  • Place of Presentation: 東京
  • Year and Date: 2012-07-14
• [Presentation] Clinical use of 4DST as a new PET molecular imaging probe to measure DNA synthesis of brain tumor. (2012)
  • Author(s): Nariai, T.
  • Organizer: The 4^<th> International symposium of brain tumor pathology
  • Place of Presentation: Nagova
  • Year and Date: 2012-05-24
• [Presentation] [^<11>C]4DST as novel PET tracer for imaging DNA synthesis in non-small cell lung cancer. (2011)
  • Author(s): Minamimoto, R.
  • Organizer: Radiological society of north America 97^<th> scientific assemble and annual meeting.
  • Place of Presentation: Chicago (USA)
  • Year and Date: 20111127-20111202
• [Presentation] Initial clinical trials of carbon-11-labeled 4DST for malignant brain tumors as a PET molecular imaging probe to measure DNA synthesis rate. (2011)
  • Author(s): Nariai, T.
  • Organizer: 16^<th> Annual scientific meeting of the society for neuro-oncology,
  • Place of Presentation: Orange County (USA)
  • Year and Date: 20111117-20111120
• [Presentation] 新規DNA合成診断薬剤^<11>C-4DSTの初期臨床評価-安全性評価と代謝分析 (2011)
  • Author(s): 豊原潤
  • Organizer: 第50回日本核医学会学術総会
  • Place of Presentation: 大宮
  • Year and Date: 20111111-20101113
• [Presentation] 新規DNA合成診断薬剤^<11>C-4DSTの非小細胞肺癌における有用性の検討 (2011)
  • Author(s): 南本亮吾
  • Organizer: 第51回日本核医学会学術総会
  • Place of Presentation: つくば市
  • Year and Date: 20111027-20111029
• [Presentation] ^<11>C-4DST PETの腫瘍と炎症の鑑別診断に関する基礎的検討 (2011)
  • Author(s): 豊原潤
  • Organizer: 第51回目本核医学会学術総会、
  • Place of Presentation: つくば市
  • Year and Date: 20111027-20111029
• [Presentation] DNA合成診断薬剤^<11>C-4DSTの悪性脳腫瘍治療効果モニターリングへの応用 (2011)
  • Author(s): 成相直
  • Organizer: 第51回日本核医学会学術総会、
  • Place of Presentation: つくば市
  • Year and Date: 20111027-20111029
• [Presentation] ^<11>C-4DST動態解析に関する基礎的検討 (2011)
  • Author(s): 豊原潤
  • Organizer: 第51回日本核医学会学術総会
  • Place of Presentation: つくば市
  • Year and Date: 20111027-20111029
• [Presentation] Evaluation of 4'-[methyl-^<11>C]thiothymidine in a rodent model of tumor and inflammation. (2011)
  • Author(s): Toyohara, J.
  • Organizer: Annual congress of the European association of nuclear medicine
  • Place of Presentation: Birmingham (UK)
  • Year and Date: 20111015-20111018
• [Presentation] PET分子イメージングの有用性と可能性 (2011)
  • Author(s): 稲次基希
  • Organizer: 第70回日本脳神経外科学会総会
  • Place of Presentation: 横浜
  • Year and Date: 20111012-20111014
• [Presentation] Clinical use of molecular imaging for the treatment of malignant brain tumor. (2011)
  • Author(s): Nariai, T.
  • Organizer: Annual meeting of congress of neurological surgeons
  • Place of Presentation: Washington DC (USA)
  • Year and Date: 20111001-20111006
• [Presentation] Initial clinical trials of carbon-11-labeled 4DST in brain tumors (2011)
  • Author(s): Toyohara, J.
  • Organizer: 58th Annual meeting of the society of nuclear medicine
  • Place of Presentation: San Antonio (USA)
  • Year and Date: 20110604-20110608
• [Presentation] DNA synthesis imaging of non-small-cell lung cancer using a new PET tracer [^<11>C]4DST. (2011)
  • Author(s): Minamimoto, R.
  • Organizer: 58^<th> Annual meeting of the society of nuclear
  • Place of Presentation: San Antonio (USA)
  • Year and Date: 20110604-20110608
• [Presentation] Kinetic modeling of [^<11>C]4DST PET imaging DNA synthesis rate : initial clinical trials in brain tumors. (2011)
  • Author(s): Sakata, M.
  • Organizer: 10^<th> International conference of quantification of brain function with PET
  • Place of Presentation: Barcelona(Spain)
  • Year and Date: 20110524-20110528
• [Presentation] 新規DNA合成診断薬剤^<11>C-4DSTの初期臨床評価-悪性脳腫瘍への臨床応用 (2010)
  • Author(s): 成相直
  • Organizer: 第50回日本核医学会学術総会
  • Place of Presentation: 大宮
  • Year and Date: 20101111-20101113
• [Presentation] 新規DNA合成診断薬剤^<11>C-4DSTの初期臨床評価一脳腫瘍での動態解析 (2010)
  • Author(s): 坂田宗之
  • Organizer: 第50回日本核医学会学術総会
  • Place of Presentation: 大宮
  • Year and Date: 20101111-20101113
• [Presentation] 新規DNA合成診断薬剤^<11>C-4DSTの初期臨床評価-全身PET画像の評価 (2010)
  • Author(s): 窪田和雄
  • Organizer: 第50回日本核医学会学術総会
  • Place of Presentation: 大宮
  • Year and Date: 20101111-20101113
• [Book] Trends on the role of PET in drug development 768 (2012)
  • Author(s): Toyohara, J. and Ishiwata, K.
  • Total Pages: 193-218
  • Publisher: World Scientific Publishing Co.
• [Book] Springer Verlag, Tumors of the central nervous system
  • Author(s): Nariai, T., Inaji, M., Sakata, M. and Toyohara, J.
  • Publisher: (in press)
• [Book] Springer Verlag, PET and SPECT for neurobiological systems
  • Author(s): Toyohara, J., Sakata, M. and Ishiwata, K.
  • Publisher: (in press)