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2012 Fiscal Year Final Research Report

Establishment of novel living tissue adhesion method by using integrated low-level energies of heat, pressure and vibration

Research Project

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Project/Area Number 22390242
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionIbaraki University

Principal Investigator

MASUZAWA Toru  茨城大学, 工学部, 教授 (40199691)

Co-Investigator(Kenkyū-buntansha) HIGAMI Tetsuya  札幌医科大学, 医学部, 教授 (60335429)
KISHIDA Akio  東京医科歯科大学, 生体材料工学研究所, 教授 (60224929)
Co-Investigator(Renkei-kenkyūsha) OZEKI Kazuhide  茨城大学, 工学部, 准教授 (20366404)
KIMURA Tsuyoshi  東京医科歯科大学, 生体材料工学研究所, 助教 (10393216)
KATOH Ayako  埼玉医科大学, 保健医療学部, 講師 (30318159)
TOSHIYUKI Aodai  松江工業高等専門学校, 電子制御工学科, 助教 (40571849)
Project Period (FY) 2010 – 2012
Keywords人工臓器学 / 手術機器 / 生体組織結合 / 生体組織接着
Research Abstract

Novel biological tissue adhesion method, which is using integrated low-level energy sources of heat, vibration and pressure, has been established. Morphological changes of collagen by heating and applying pressure were observed. It seems that thermal cross-links of collagen fibers could contribute the adhesion strength. We succeeded in shortening the adhesion time to 20 sec by developing specialized heater control unit. The adhesion performance with metal specimen can be regulated by using DLC coating and changing the roughness of metal surface. The polymer material with polar groups can be adhered on the living tissue. In animal experiments, no inflammation was observed, the tissue construction could be preserved well and the adhesion performance could be kept for more than 1 month in the living body.

  • Research Products

    (38 results)

All 2013 2012 2011 2010 Other

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (20 results) Book (2 results) Remarks (1 results) Patent(Industrial Property Rights) (6 results) (of which Overseas: 2 results)

  • [Journal Article] Influence of the source gas ratio on the hydrogen and deuterium content of a-C:H and a-C:D films: Plasma-enhanced CVD with CH_4/H_2, CH_4/D_2, CD_4/H_2 and CD_4/D_22013

    • Author(s)
      Ozeki K, Sekiba D, Suzuki T. Kanda K, Niibe M, Hirakuri K K, and Masuzawa T
    • Journal Title

      Applied Surface Science

      Volume: 265巻 Pages: 750-757

    • Peer Reviewed
  • [Journal Article] Effect of metal surface characteristics on the adhesion performance of the integrated low-level energies method of adhesion2012

    • Author(s)
      Aodai T, Masuzawa T, Ozeki K, Kishida A, and Higami T
    • Journal Title

      Journal of Artificial Organs

      Volume: 15巻 Pages: 386-394

    • Peer Reviewed
  • [Journal Article] Fabrication of a heterostructural fibrillated collagen matrix for the regeneration of soft tissue function2012

    • Author(s)
      Kwangwoo Nam, Sakai Y, Hashimoto Y, Kimura T, Kishida A
    • Journal Title

      Soft Matter

      Volume: 8巻 Pages: 472-480

    • Peer Reviewed
  • [Journal Article] Effects of vibration on differentiation of cultured PC12 cells2011

    • Author(s)
      Ito Y, Kimura T, Kwangwoo Nam, Katoh A, Masuzawa T, Kishida A
    • Journal Title

      Biotechnology and Bioengineering

      Volume: 108(3)巻 Pages: 592-599

    • Peer Reviewed
  • [Journal Article] Synthetic polymer?tissue adhesion using an ultrasonic scalpel2011

    • Author(s)
      Yamamoto K,Kimura T,Kwangwoo Nam,Funamoto S,Ito Y,Shiba K,Ayako Katoh,Shimizu S,Kurita K,Higami T,Masuzawa T,Kishida A
    • Journal Title

      Surgical Endoscopy

      Volume: 25巻 Pages: 1270-1275

    • Peer Reviewed
  • [Journal Article] Effect of treatment temperature on collagen structures of the decellularized carotid artery using high hydrostatic pressure2011

    • Author(s)
      Negishi J, Funamoto S, Kimura T, Kwangwoo Nam, Higami T, Kishida A
    • Journal Title

      Journal of Artificial Organs

      Volume: 14(3) Pages: 223-231

    • Peer Reviewed
  • [Journal Article] Engineering a Collagen Matrix that Replicates the Biological Properties of Native Extracellular Matrix2011

    • Author(s)
      Kwangwoo Nam, Sakai Y, Funamoto S, Kimura T, Kishida A
    • Journal Title

      Journal of Biomaterials Science-Polymer Edition

      Volume: 22巻 Pages: 1963-1982

    • Peer Reviewed
  • [Journal Article] Nano-vibration effect on cell adhesion and its shape2011

    • Author(s)
      Ito Y, Kimura T, Ago Y, Kwangwoo Nam, Hiraku K, Miyazaki K, Masuzawa T, Kishida A
    • Journal Title

      Bio-Medical Materials and Engineering

      Volume: 21(3)巻 Pages: 149-158

    • Peer Reviewed
  • [Journal Article] Development of tissue adhesion method using integrated low-level energies2010

    • Author(s)
      Katoh A, Masuzawa T, Ozeki K, Kishida A, Kimura T, and Higami T
    • Journal Title

      Medical Engineering & Physics

      Volume: 32巻 Pages: 304-311

    • Peer Reviewed
  • [Presentation] 表面グラフト改質高分子を用いた生体組織接着に関する研究2013

    • Author(s)
      岩田拓也, 岸田晶夫
    • Organizer
      第22回ライフサポート学会フロンティア講演会
    • Place of Presentation
      東京
    • Year and Date
      2013-03-02
  • [Presentation] 複合低エネルギーを用いた組織接合法のin vivo評価2012

    • Author(s)
      丸岡寛明,増澤徹
    • Organizer
      第50回人工臓器学会大会
    • Place of Presentation
      福岡
    • Year and Date
      20121122-24
  • [Presentation] Preparation of biological tissue-polymer complex for percutaneous device2012

    • Author(s)
      Matsushima R, Kishida A
    • Organizer
      TERMIS World Congress 2012
    • Place of Presentation
      Vienna
    • Year and Date
      20120905-08
  • [Presentation] Investigation of interaction between the polymer surface and collagen molecules during fibrillogenesis2012

    • Author(s)
      Kwangwoo Nam, Kishida A
    • Organizer
      9th World Bio- materials Congress
    • Place of Presentation
      Chengdu
    • Year and Date
      20120601-05
  • [Presentation] メタン及びアルゴンガスによる高分子上へのDLC成膜と物性評価2012

    • Author(s)
      尾関和秀,増澤徹
    • Organizer
      第26回ダイヤモンドシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2012-11-20
  • [Presentation] 生体組織接着のための組織融着装置の開発と基礎的検討2012

    • Author(s)
      原田亮, 樋上哲哉
    • Organizer
      第51回日本生体医工学学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2012-05-11
  • [Presentation] 複合低エネルギを用いた鉗子型組織接合装置の開発2012

    • Author(s)
      丸岡寛明,増澤徹
    • Organizer
      第51回日本生体医工学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2012-05-10
  • [Presentation] 微小振動下における細胞接着過程の検討2011

    • Author(s)
      木村剛,岸田晶夫
    • Organizer
      生活生命支援医療福祉工学系学会連合大会2011
    • Place of Presentation
      東京
    • Year and Date
      20111103-1105
  • [Presentation] 生体組織/高分子複合化による経皮デバイスの作製2011

    • Author(s)
      松嶋理恵,岸田晶夫
    • Organizer
      生活生命支援医療福祉工学系学会連合大会2011
    • Place of Presentation
      東京
    • Year and Date
      20111103-1105
  • [Presentation] 複合低エネルギによる鉗子型融着デバイスの温度制御技術2011

    • Author(s)
      丸岡寛明,増澤徹
    • Organizer
      生活生命支援医療福祉工学系学会連合大会2011
    • Place of Presentation
      東京
    • Year and Date
      20111103-1105
  • [Presentation] Development of percutaneous device based on nature tissue-polymer complex2011

    • Author(s)
      Kwangwoo Nam,Kishida A
    • Organizer
      The 3rd Asian Biomaterials Congress
    • Place of Presentation
      Busan Korea
    • Year and Date
      20110915-17
  • [Presentation] 医療用高分子材料の表面特性と接着2011

    • Author(s)
      中村奈緒子,岸田晶夫
    • Organizer
      第50回日本生体医工学会大会
    • Place of Presentation
      東京
    • Year and Date
      20110429-0501
  • [Presentation] 複合低エネルギによる鉗子型組織接合装置の開発2011

    • Author(s)
      青代敏行,増澤徹
    • Organizer
      第50回日本生体医工学会大会
    • Place of Presentation
      東京
    • Year and Date
      20110429-0501
  • [Presentation] 微小振動を用いた小型組織融着装置の開発2011

    • Author(s)
      笠原康佑,岸田晶夫
    • Organizer
      第20回ライフサポート学会フロンティア講演会
    • Place of Presentation
      東京電機大学(東京)
    • Year and Date
      2011-03-05
  • [Presentation] 複合低エネルギを用いた金属と生体組織の接合技術2011

    • Author(s)
      丸岡寛明,増澤徹
    • Organizer
      第20回ライフサポート学会フロンティア講演会
    • Place of Presentation
      東京電機大学(東京)
    • Year and Date
      2011-03-05
  • [Presentation] 複合低エネルギによる心筋組織接合技術の開発2010

    • Author(s)
      青代敏行,増澤徹
    • Organizer
      電気学会リニアドライブ研究会
    • Place of Presentation
      仙台国際センター(仙台)
    • Year and Date
      2010-11-20
  • [Presentation] 複合低エネルギによる金属と生体組織接合技術の開発2010

    • Author(s)
      青代敏行,増澤徹
    • Organizer
      第48回日本人工臓器学会大会
    • Place of Presentation
      仙台国際センター(宮城)
    • Year and Date
      2010-11-18
  • [Presentation] 低エネルギ生体融着デバイスの発熱機構の開発2010

    • Author(s)
      猪野学,増澤徹
    • Organizer
      生活生命支援医療福祉工学系連合大会
    • Place of Presentation
      大阪大学(大阪)
    • Year and Date
      2010-09-18
  • [Presentation] 微小振動融着法を用いた高分子コラーゲン間の接着2010

    • Author(s)
      笠原康佑,岸田晶夫
    • Organizer
      生活生命支援医療福祉工学系連合大会
    • Place of Presentation
      大阪大学(大阪)
    • Year and Date
      2010-09-18
  • [Presentation] Adhesion technology using integrated low level energies2010

    • Author(s)
      加藤綾子,増澤徹
    • Organizer
      第49回日本生体医工学会大会
    • Place of Presentation
      大阪国際交流センター(大阪)
    • Year and Date
      2010-06-25
  • [Book] 人工臓器は,いま-暮らしのなかにある最先端医療の姿(第15章人工歯根)2012

    • Author(s)
      尾関和秀
    • Total Pages
      447-465
    • Publisher
      はる書房
  • [Book] ものづくり技術からみる再生医療?細胞研究・創薬・治療? (第7章バイオマテリアルの生体適合性の評価)2011

    • Author(s)
      田畑泰彦
    • Total Pages
      152-160
    • Publisher
      シーエムシー出版
  • [Remarks]

    • URL

      http://www.mech.ibaraki.ac.jp/masuzawa-lab/h22kaken/kaken01.html

  • [Patent(Industrial Property Rights)] 組織自己接合型体内挿入管及び該体内挿入管との接合方法2012

    • Inventor(s)
      増澤徹,青代敏行
    • Industrial Property Rights Holder
      国立大学法人 茨城大学
    • Industrial Property Number
      特願2012-111902
    • Filing Date
      2012-08-03
  • [Patent(Industrial Property Rights)] 生体組織接着装置2012

    • Inventor(s)
      岸田晶夫,増澤徹
    • Industrial Property Rights Holder
      国立大学法人 東京医科歯科大学,国立大学法人 茨城大学
    • Industrial Property Number
      特許5028607号
    • Filing Date
      2012-07-06
  • [Patent(Industrial Property Rights)] 生体組織接着用柔軟性金属箔テープ及びその接着方法2010

    • Inventor(s)
      尾関和秀,増澤徹,岸田晶夫,加藤綾子
    • Industrial Property Rights Holder
      国立大学法人 茨城大学
    • Industrial Property Number
      特願2010-229738
    • Filing Date
      2010-10-12
  • [Patent(Industrial Property Rights)] 生体組織と人工物の接着装置,ステント2010

    • Inventor(s)
      増澤徹,尾関和秀,岸田晶夫,加藤綾子
    • Industrial Property Rights Holder
      国立大学法人 茨城大学,国立大学法人 東京医科歯科大学
    • Industrial Property Number
      特願2011-510193
    • Filing Date
      2010-04-20
  • [Patent(Industrial Property Rights)] 生体組織と人工物の接着装置,ステント2010

    • Inventor(s)
      増澤徹,尾関和秀,岸田晶夫,加藤綾子
    • Industrial Property Rights Holder
      国立大学法人 茨城大学,国立大学法人 東京医科歯科大学
    • Industrial Property Number
      PCT/JP2010/002828
    • Filing Date
      2010-04-20
    • Overseas
  • [Patent(Industrial Property Rights)] 生体組織接着装置2010

    • Inventor(s)
      岸田晶夫,増澤徹
    • Industrial Property Rights Holder
      国立大学法人 東京医科歯科大学,国立大学法人 茨城大学
    • Industrial Property Number
      PCT/JP2010/059375
    • Filing Date
      2010-06-02
    • Overseas

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Published: 2014-08-29  

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