2012 Fiscal Year Final Research Report
Molecular pathological analyses of collateral augmentation for a development of novel angiogenic therapy
| Project/Area Number |
22390245
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHIGEMATSU Kunihiro 東京大学, 医学部附属病院, 講師 (20215966)
OKAMOTO Hiroyuki 東京大学, 医学部附属病院, 特任講師 (60348266)
HOSHINA Katsuyuki 東京大学, 医学部附属病院, 助教 (90571761)
KOYAMA Hiroyuki 東京大学, 医学部附属病院, 特任准教授 (10241994)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 血管外科学 / 再生医療 |
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| Research Abstract |
In the present study, we first assessed a process of collateral augmentation in the rabbit model of limb ischemia. After an excision of the left femoral artery, main route of collateral vessels was developed between the left inferior gluteal artery and the left popliteal artery, which was located in the left coccygeo-femoral muscle. Based on the findings, we selectively administrated basic fibroblast growth factor (bFGF) or bone marrow mononuclear cells (MN) to the left coccygeo-femoral muscle or the left adductor muscle at 28 days after femoral artery removal. At 28 days after administration of bFGF or MN, limb ischemia after the delivery to the coccygeo-femoral muscle were significantly improved as compared with those to the adductor muscle, suggesting that selection of delivery target was an important factor to promote effective collateral augmentation.
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