2012 Fiscal Year Final Research Report
Experimental research of immunological tolerance in allograft from cadaveric donors for clinical trial
| Project/Area Number |
22390246
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
高原 史郎 大阪大学, 医学系研究科, 寄附講座教授 (70179547)
矢澤 浩治 大阪大学, 医学系研究科, 助教 (40569109)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 移植外科学 |
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| Research Abstract |
During the study period, it was revealed in Rhesus monkeys that anti-human thymocyte globulin may reduce the number of T-cell, that chimerism of peripheral blood mononuclear cells (PMBC) can be detected and that bone marrow transplant can be done by perfusion technique. Although chimerism of PBMC was not observed, mixed lymphocyte reaction (MLR) against the donor lymphocytes was significantly reduced compared to that against lymphocytes of third party monkey
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