2012 Fiscal Year Final Research Report
Clinical significance of serum exosomal micro RNA in human esophageal squamous cellcarcinoma
| Project/Area Number |
22390247
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kumamoto University |
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Principal Investigator |
BABA Hideo 熊本大学, 大学院・生命科学研究部, 教授 (20240905)
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| Co-Investigator(Kenkyū-buntansha) |
HAYASHI Naoko 熊本大学, 医学部附属病院, 非常勤診療医師 (20452899)
WATANABE Masayuki 熊本大学, 大学院・生命科学研究部, 准教授 (80254639)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 食道癌 / miR / miRNA |
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| Research Abstract |
Exosomes are 40-nm to 100-nm membrane vesicles that are secreted by various cells, andthey play a major role in cell-cell communication. The expression levels of exosomalmiR-21 were significantly higher in patients with ESCC than those with benign diseases.Exosomal miR-21 was positively correlated with tumor progression and aggressiveness,suggesting that it may be a useful target for cancer therapy.
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[Journal Article] Micro RNA- 200b regulates cellproliferation, invasion and migrationby directly targeting ZEB2 in gastriccarcinoma2012
Author(s)
Kurashige J, Kamohara H, Watanabe M,Hiyoshi Y, Iwatsuki M, Tanaka Y,Kinoshita K, Saito S, Baba Y, Baba H
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Journal Title
Ann Surg Oncol 19 Suppl
Volume: 3
Pages: 656-64
DOI
Peer Reviewed
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