Analysis of carcinogenic mechanism of biliary tract cancer from the protein control by ubiquitin ligase Fbw7

2012 Fiscal Year Final Research Report

• Project/Area Number: 22390252
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Tohoku University
• Principal Investigator: KATAYOSE Yu 東北大学, 大学院・医学系研究科, 准教授 (20302151)
• Co-Investigator(Kenkyū-buntansha): YAMAMOTO Kuniharu 東北大学, 大学院・医学系研究科, 非常勤講師 (00375073) ; YOSHIDA Hiroshi 東北大学, 病院, 講師 (60436152) ; NAKAGAWA Kei 東北大学, 大学院・医学系研究科, 助教 (20542294) ; HAYASHI Hiroshi 東北大学, 病院, 助教 (30422124)
• Project Period (FY): 2010 – 2012
• Keywords: 胆道癌 / ユビキチンリガーゼ / Fbw7

Research Abstract

The gene variation of Fbw7 of a biliary tract cancer cell line was considered, three sorts of isoform(s) of alpha-beta-gamma existed, and especially the expression level of gamma traced that it was low in predominance by all the cell strains in order to solve the role of Fbw7 in a biliary tract cancer occurrence. Next, in order to solve protein control of a biliary tract cancer, the Mouse Embryonic Fibroblast (MEF) of Fbxw7 conditional KO (CKO) mouse, CDK inhibitor showed clearly to have received the complicated control by the proteolytic mechanism by Fbxw7.

Research Products

• [Journal Article] Efficacy of neoadjuvant chemoradiation therapy forclinical Stage II cholangiocarcinoma as apreoperative diagnosis (2012)
  • Author(s): Nakagawa K, Katayose Y, Unno M.
  • Journal Title: Gan To Kagaku Ryoho Volume: 39(12) Pages: 1945-1947
  • URL: http://www.pieronline.jp/content/arti cle/0385-0684/39120/1945
  • Peer Reviewed
• [Journal Article] An analysis of asecond-line S-1 monotherapy for gemcitabine-refractory biliary tract cancer (2012)
  • Author(s): Katayose Y, Ohtsuka H, Kitamura Y, Masuda K, Nakagawa K, Yamamoto K, Yoshida H, Onogawa T, Motoi F, Naitoh T, Rikiyama T, Egawa S, Unno M.
  • Journal Title: Hepatogastroenterology Volume: 59(115) Pages: 691-695
  • DOI: doi:10.5754
  • Peer Reviewed
• [Journal Article] Lymph nodes metastasis is a risk factor for bone metastasis from extrahepatic cholangiocarcinoma (2012)
  • Author(s): Katayose Y, Nakagawa K, Yamamoto K, Yoshida H, Hayashi H, Mizuma M, Ohtsuka H, Fukase K, Onogawa T, Motoi F, Rikiyama T, Egawa S, Unno M
  • Journal Title: Hepatogastroenterology Volume: 59(118) Pages: 1758-1760
  • DOI: doi:10.5754
  • Peer Reviewed
• [Journal Article] Phase I trial of neoadjuvant chemoradiation with gemcitabine and surgical resection for cholangiocarcinoma patients (NACRAC study) (2011)
  • Author(s): Katayose Y, Rikiyama T, Motoi F, Yamamoto K, Yoshida H, Morikawa T, Hayashi H, Kanno A, Hirota M, Satoh K, Ariga H, Suzuki M, Ohyauchi M, Kondo Y, Ikeya S, Ogawa Y, Shimosegawa T, Egawa S, Unno M.
  • Journal Title: Hepatogastroenterology Volume: 58(112) Pages: 1866-1872
  • DOI: 10.5754/hge10106
  • Peer Reviewed
• [Presentation] ゲムシタビン耐性胆道癌に対するS-1の効果と有害事象の検討 (2012)
  • Author(s): 片寄友
  • Organizer: 第48回日本胆道学会総会
  • Place of Presentation: 東京
  • Year and Date: 20120920-20120921
• [Presentation] CD133-expressing Cells Have Cancer Stem Cell-like Properties in Cholangiocarcinoma (2012)
  • Author(s): Yo Kitamura, Yu Katayose, Kei Nakagawa , Hiroshi Yoshida, et al
  • Organizer: 22nd Biennial European Association for Cancer Research(EACR) Congress
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 20120707-20120710
• [Presentation] StageII胆管癌への術前化学放射線療法の意義 (2012)
  • Author(s): 中川圭
  • Organizer: 第24回日本肝胆膵外科学会
  • Place of Presentation: 大阪
  • Year and Date: 20120530-20120601
• [Presentation] 胆管癌におけるCD133陽性細胞の特徴 (2012)
  • Author(s): 北村洋、片寄友、中川圭、吉田寛, 他
  • Organizer: 第112回日本外科学会総会
  • Place of Presentation: 千葉
  • Year and Date: 20120412-20120414