2013 Fiscal Year Final Research Report
Molecular mechanisms responsible for the development of scirrhous gastric cancer: analysis of cancer stem cells.
| Project/Area Number |
22390262
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Osaka City University |
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Principal Investigator |
HIRAKAWA Kosei 大阪市立大学, 医学(系)研究科(研究院), 教授 (40188652)
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| Co-Investigator(Kenkyū-buntansha) |
YASHIRO Masakazu 大阪市立大学, 大学院・医学研究科, 准教授 (60305638)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | スキルス胃癌 / 癌幹細胞 / 胃癌由来線維芽細胞 / TGFβ / integrin / 腹膜転移 |
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| Research Abstract |
Scirrrhous gastric cancer frequently develops into peritoneal metastasis, resulting in a poor prognosis. Cancer stem cells (CSCs) are considered to be responsible for cancer metastasis. The side population (SP), as evaluated by a flowcytometic analysis has been known as CSCs rich population. The aim of this study is to clarify the characterization of the SP cells in peritoneal metastasis of gastric carcinoma and to determine an effective signal inhibitor with effects on the proliferation of CSC. We used three gastric cancer cell lines and three SP-enriched CSC cell lines. CSCs-like SP cells expressing integrin, and CD44 may play an important role for peritoneal metastasis in gastric carcinoma. CSCs have chemoresistance to irinotecan. c-Met inhibitor may be a promising target molecule for irinotecan-based chemotherapy of gastric cancer. CAFs might regulate the stemness of CSCs in scirrhous gastric cancer by TGF-beta signaling.
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[Journal Article] Design and synthesis of a series of alpha-benzyl phenylpropanoic acid-type peroxisome proliferator-activated receptor (PPAR) gamma partial agonists with improved aqueous solubility2013
Author(s)
Ohashi M, Oyama T, Putranto EW, Waku T, Nobusada H, Kataoka K, Matsuno K, Yashiro M, Morikawa K, Huh NH, Miyachi H
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Journal Title
BioorgMed Chem
Volume: 21
Pages: 2319-32
Peer Reviewed
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[Journal Article] SPan-1 is a useful prognostic marker for patients with stage IV gastric cancer who underwent palliative gastrectomy : a retrospective multivariate study2013
Author(s)
Kubo N, Ohira M, Sakurai K, Toyokawa T, Tanaka H, Muguruma K, Nagahara H, Kimura K, Noda E, Amano R, Yamada N, Yashiro M, Maeda K, Sawada T, Hirakawa K
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Journal Title
World J Surg
Volume: 37
Pages: 1681-7
Peer Reviewed
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[Journal Article] MUC1 and HER2 might be associated with invasive phenotype of intraductal papillary mucinous neoplasm (IPMN)2013
Author(s)
Ohira G, Kimura K, Ymada N, Amano R, Nakata B, Doi Y, Murata A, Yashiro M, Tanaka S, Ohsawa M, Wakasa K, Hirakawa K
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Journal Title
Hepatogastroenterology
Volume: 60
Peer Reviewed
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[Journal Article] Hypoxia stimulates the EMT of gastric cancer cells through autocrine TGFbeta signaling2013
Author(s)
Matsuoka J, Yashiro M, Doi Y, Fuyuhiro Y, Kato Y, Shinto O, Aomatsu N, Hirakawa T, Hasegawa T, Shimizu K, Shimizu T, Miwa A, Yamada N, Sawada T, Hirakawa K
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Journal Title
PLoS One
Volume: 8
Pages: e62310
Peer Reviewed
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[Journal Article] Successful resection of esophageal cancer with right aortic arch by video-assisted thoracoscopic surgery : a case report2013
Author(s)
Kubo N, Ohira M, Lee T, Sakurai K, Toyokawa T, Tanaka H, Muguruma K, Kimura K, Nagahara H, Noda E, Amano R, Ohtani H, Yamashita Y, Yashiro M, Maeda K, Hirakawa K
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Journal Title
Anticancer Res
Volume: 33
Pages: 1635-40
Peer Reviewed
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[Journal Article] Predictive value of expression of ERCC 1 and GST-p for 5-fluorouracil/oxaliplatin chemotherapy in advanced colorectal cancer2013
Author(s)
Noda E, Maeda K, Inoue T, Fukunaga S, Nagahara H, Shibutani M, Amano R, Nakata B, Tanaka H, Muguruma K, Yamada N, Yashiro M, Ohira M, Ishikawa T, Hirakawa K
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Journal Title
Hepatogastroenterology
Volume: 59
Pages: 130-3
Peer Reviewed
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[Journal Article] Foretinib (GSK1363089), a multi-kinase inhibitor of MET and VEGFRs, inhibits growth of gastric cancer cell lines by blocking inter-receptor tyrosine kinase networks2012
Author(s)
Kataoka Y, Mukohara T, Tomioka H, Funakoshi Y, Kiyota N, Fujiwara Y, Yashiro M, Hirakawa K, Hirai M, Minami H
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Journal Title
Invest New Drugs
Volume: 30
Pages: 1352-60
Peer Reviewed
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[Journal Article] Successful resection of esophageal carcinoma associated with double aortic arch : a case report2012
Author(s)
Kubo N, Ohira M, Yamashita Y, Sakurai K, Kimura K, Nagahara H, Noda E, Amano R, Yashiro M, Maeda K, Hirakawa K
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Journal Title
Anticancer Res
Volume: 32
Pages: 3351-5
Peer Reviewed
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[Journal Article] Polymeric micelles incorporating (1,2-diaminocyclohexane)platinum (II) suppress the growth of orthotopic scirrhous gastric tumors and their lymph node metastasis2012
Author(s)
Rafi M, Cabral H, Kano MR, Mi P, Iwata C, Yashiro M, Hirakawa K, Miyazono K, Nishiyama N, Kataoka K
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Journal Title
J Control Release
Volume: 159
Pages: 189-96
Peer Reviewed
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[Journal Article] Transforming growth factor-beta decreases the cancer-initiating cell population within diffuse-type gastric carcinoma cells2011
Author(s)
Ehata S, Johansson E, Katayama R, Koike S, Watanabe A, Hoshino Y, Katsuno Y, Komuro A, Koinuma D, Kano MR, Yashiro M, Hirakawa K, Aburatani H, Fujita N, Miyazono K
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Journal Title
Oncogene.
Volume: 30
Pages: 1693-705
Peer Reviewed
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[Presentation] An EGFR inhibitor enhances the efficacy of SN38, an active metabolite of irinotecan, in SN38-refractory gastric carcinoma cells2012
Author(s)
Yashiro M, Fukuoka T, Kinoshita H, Nishii T, Hasegawa T, Matsuzaki T, Morisaki T, Hirakawa K
Organizer
American Association for Cancer Research 103rd Annual Meeting.
Place of Presentation
Convention Center, Chicago
Year and Date
2012-04-04
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