2012 Fiscal Year Final Research Report
Cardiac Regeneration using 3-Dimensional Cardiac Tissue
| Project/Area Number |
22390267
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Saga University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NODE Kouichi 佐賀大学, 医学部, 教授 (80359950)
NAKAYAMA Kouichi 佐賀大学, 工学系研究科, 教授 (50420609)
NOGUCHI Ryo 佐賀大学, 医学部, 助教 (70530187)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 心臓大血管外科学 / 再生医療 / 心筋再生 / 組織工学 |
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| Research Abstract |
We fabricated scaffold-free 3-Dimensional functional cardiac tissue using spheroid based technology. Proper cardiac tissue spheroids are fabricated with cardiomyocytes, dermal fibroblasts, and vascular endothelial cells. We also fabricated 3-D cardiac tissue with the diameter 1cm, and these constructs were implanted to nude rat heart. Furthermore, implantation for acute myocardial infarction nude rat model indicates improvement of left ventricular ejection fraction.
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