2012 Fiscal Year Final Research Report
Fundamental study of an anti-adhesive membrane for thoracic surgeries
| Project/Area Number |
22390268
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAWADA Hajime 横浜市立大学, 医学研究科, 教授 (90101112)
ITO Hiroshi 横浜市立大学, 医学研究科, 客員教授 (80124303)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 癒着防止膜 / 外科 / 細胞・組織 / 臨床 |
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| Research Abstract |
A pilot study for an anti-adhesive membrane for thoracic surgeries especially for the pleural cavity surgery was performed. A biodegradable membrane made of gelatin or hyaluronic-acid containing a certain amount of glycerin was developed. In vivo and in vitro studies showed that the tested membranes were effective to prevent adhesion in the pleural cavity. The mechanism of these desirable results was as follows. The membranes contained glycerin, which gathered and dispersed abundant water. Together with this, growth factors are also dispersed, resulting in dilution of excessive growth factors at the wound sites.
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[Journal Article] Elevated m i c r o s a t e l l i t e a l t e r a t i o n s a t selected tetra-nucleotide (EMAST) in non - small cell lung cancers - a potential determinant of susceptibility to multiple malignancies2013
Author(s)
H. Arai, K Okudera, H. Oshiro, N. Komitsu, H. Mitsui, T. Nishi, M. Tsuboi, A. Nozawa, Y. Noishiki, K. Ohhashi, K. Inui,M.Masuda
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Journal Title
Int. J. Clin. Exp Patho
Volume: 6
Pages: 359-410
Peer Reviewed
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