2012 Fiscal Year Final Research Report
Gene and molecular therapy for malignant brain tumors using drug-resistant genes
| Project/Area Number |
22390277
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kagawa University |
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Principal Investigator |
TAMIYA Takashi 香川大学, 医学部脳神経外科, 教授 (50252953)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAI Nobuyuki 香川大学, 医学部, 准教授 (40294756)
MIYAKE Keisuke 香川大学, 医学部, 講師 (00398033)
OKADA Masaki 香川大学, 医学部, 病院助教 (40457346)
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| Project Period (FY) |
2010 – 2012
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| Keywords | ABCG2 / MGMT / Glioblastoma / Positron emissionTomography / Methionine / FLT / FMISO |
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| Research Abstract |
We would like to examine the relationship between the therapeutic efficacy of radiation therapy or anti-cancer drugs and expression of drug resistance gene, in order to develop a new molecular therapy. We examined in detail the time of initial and recurrence state of expression of drug resistance gene-protein of malignant glioma. We also examined the relationship between expression of the drug resistance gene and PET studies using radionuclide methionine, FLT, and FMISO. As a result, the amplification of the gene expression was observed in the ABCG2 and MDR1, MRP1, MRP2 especially drug resistance gene protein in human malignant glioblastoma at the time of relapse. In addition, analyzes using PET study in clinical cases of malignant gliomas, the uptake of FLT and methionine correlate with cell proliferation of malignant gliomas. In addition, the uptake of FMISO positively correlated with the expression of the drug resistance gene protein.
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[Journal Article] 3'-Deoxy-3'-[(18)F]-fluorothymidine ([(18)F]-FLT) transport in newly diagnosed glioma: correlation with nucleoside transporter expression, vascularization, and blood-brain barrier permeability.2013
Author(s)
Shinomiya A, Miyake K, Okada M, Nakamura T, Kawai N, Kushida Y, Haba R, Kudomi N, Tokuda M, Tamiya T
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Journal Title
Peer Reviewed
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