2012 Fiscal Year Final Research Report
Functional analysis of Sox11 and Plagl1 in glioma stem cells.
| Project/Area Number |
22390278
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Hokkaido University (2012)
Ehime University (2010-2011) |
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Principal Investigator |
KONDO Toru 北海道大学, 遺伝子病制御研究所, 教授 (30270573)
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| Co-Investigator(Renkei-kenkyūsha) |
OHNISHI Takanori 愛媛大学, 大学院・医学系研究科, 教授 (70233210)
KOMATSU Kenshi 京都大学, 放射線生物研究センター, 教授 (80124577)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 脳腫瘍学 / グリオーマ幹細胞 |
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| Research Abstract |
We have examined about the expression of Sox11 and Plagl1 and their functions in glioma stem cells (GSC) and neural stem cells (NSC) and found the following results. (1) Expression of Sox11 in GSC is not regulated by either NeuroD or Neurogenin, both of which induce Sox11 expression in neural differentiation. We have identified the DNA domain (200bp) that regulates Sox11 expression in GSC. (2) Plagl1 is involved in both the maintenance of stemness in NSC and their DNA repair. (3) We have established efficient methods for human GSC preparation and their maintenance and examined their expression profiles.
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Research Products
(22 results)
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[Journal Article] Combination of a Ptgs2 inhibitor and an EGFR signaling inhibitor prevents tumorigenesis of oligodendrocyte -lineage derived glioma-initiating cells2011
Author(s)
Hide, T., Takezaki, T., Nakatani, Y., Nakamura, H., Kuratsu, J., & Kondo, T
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Journal Title
Stem Cells
Volume: 29
Pages: 590-599
DOI
Peer Reviewed
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[Journal Article] Cytotoxic T lymphocytes efficiently recognize human colon cancer stem-like cells2011
Author(s)
Inoda, S., Hirohashi, Y., Torigoe, T., Morita, R., Takahashi, A., Asanuma, H.,Nakatsugawa, M., Nishizawa, S., Tamura, Y., Tsuruma, T., Terui, T., Kondo, T., Ishitani, K., Hasegawa, T., Hirata, K., & Sato, N
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Journal Title
Am. J. Pathol
Volume: 178
Pages: 1805-1813
DOI
Peer Reviewed
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[Journal Article] Essential role of the Hedgehog signaling pathway in human glioma-initiating cells2011
Author(s)
Takezaki, T., Hide, T., Takanaga, H., Nakamura, H., Kuratsu, J., & Kondo, T
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Journal Title
Cancer Science
Volume: 102
Pages: 1306-1312
DOI
Peer Reviewed
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