2012 Fiscal Year Final Research Report
Regulation of chondrocyte differentiation through G protein signal
| Project/Area Number |
22390286
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OGATA Naoshi 東京大学, 大学院・医学系研究科, 講師 (10361495)
NAKAMURA Kozo 国立障害者リハビリテーションセンター, 自立支援局, 局長 (60126133)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 軟骨代謝 / G 蛋白 |
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| Research Abstract |
PTHrP signal through both G alpha s and G alpha q play important roles in regulation of chondrocyte differentiation, although a precise mechanism is not clear. In this study, we have tried to establish mouse model of both overexpression of either G alpha s or G alpha q in chondrocyte and also establish conditional knock-out mice of either G alpha s or G alpha q in chondrocytes to explore the specific roles of G alpha s and G alpha q in chondrocytes. Moreover, we have explored to find any proteins that interact directly with PTHrP receptor or downstream of its signal and examined any involvement in chondrocyte differentiation.
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