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2012 Fiscal Year Final Research Report

Development of next generation FES equipped with ES-cell derived motoneuron

Research Project

  • PDF
Project/Area Number 22390288
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionNagoya University

Principal Investigator

HIRATA Hitoshi  名古屋大学, 医学系研究科, 教授 (80173243)

Co-Investigator(Kenkyū-buntansha) TATEBE Masahiro  名古屋大学, 医学部附属病院, 講師 (60420379)
SHINOHARA Takaaki  名古屋大学, 医学部附属病院, 助教 (00378209)
YAMAMOTO Michiro  名古屋大学, 医学部附属病院, 病院助教 (90528829)
OBINATA Goro  名古屋大学, エコトピア科学研究所, 教授 (50111315)
TORIHASHI Shigeko  名古屋大学, 医学系研究科, 教授 (90112961)
OKUI Nobuyuki  名古屋大学, 医学部附属病院, 病院助教 (70547554)
Project Period (FY) 2010 – 2012
Keywords健康・福祉工学 / 機能的電気刺激
Research Abstract

In contrast to cardiac muscle or smooth muscles, re-innervation is a prerequisite not only for functional recovery but also for survival of striated muscles. However, severe neuronal damage at higher levels such as complete spinal cord injury has little chance of recovery. Should the damaged nerve tissue be reconstructed by means of regenerative medicine technologies, optimal functional recovery would be less likely to occur due to extremely long recovering time of neural network. In this experimental study, we tried to develop a technology that allows swift re-innervation and functional recovery of striated muscles even in such situations by implanting motoneurons near paralyzed striated muscles. We first developed an ES-cell derived motoneuron integrated microelectrode array, however, due to difficulty of long time maintaining of cells on chips in vivo, we abandoned the technology. We thendeveloped a novel technology named motoneuron integrated striated muscles (MISM). Development of MISM technology consists of 4 parts, i.e. induction of motoneurons that can stably form functional neuromuscular junctions from pluripotent stem cells, transplantation of induced motoneurons into Wallerian degenerated peripheral nerve trunk, development of implantable FES system that , and motioncontrol by tacit learning program based functional electrical stimulation.

  • Research Products

    (11 results)

All 2013 2012 2011

All Journal Article (4 results) (of which Peer Reviewed: 3 results) Presentation (6 results) Book (1 results)

  • [Journal Article] Comparison of Robot-Aided Shoulder Exercise to Weight-Based Exercise2012

    • Author(s)
      Y. Pei, Y. Kim, G. Obinata, E. Genda and D. Stefanov
    • Journal Title

      International Journal of Advanced Robotic Systems

      Volume: Vol.9, No.86 Pages: 1-12

    • Peer Reviewed
  • [Journal Article] Vision-Based Tactile Sensing and Shape Estimation Using a Fluid-Type Touchpad2012

    • Author(s)
      Y. Ito, Y. Kim, C. Nagai and G. Obinata
    • Journal Title

      IEEE Transaction on Automation Science and Engineering

      Volume: Vol.9, No.4 Pages: 737-744

    • Peer Reviewed
  • [Journal Article] 新しい医療技術2012

    • Author(s)
      栗本秀、加藤宗一、平田仁、他
    • Journal Title

      幹細胞移植を用いた麻痺筋の再建(解説)整形・災害外科

      Volume: 55 Pages: 895-898

  • [Journal Article] Mesenchymal stem cells originating from ES cells show high telomerase activity and therapeutic benefits.2011

    • Author(s)
      Ninagawa N, Murakami R, Isobe E, Tanaka Y, Nakagawa H, Torihashi S
    • Journal Title

      Differentiation

      Volume: 82(3) Pages: 153-64

    • Peer Reviewed
  • [Presentation] Transplanted cell number is a key factor for success of ambulation function restoration by motoneuron integrated striated muscles2013

    • Author(s)
      Kato S, Kurimot S, Hirata H et al
    • Organizer
      Orthopaedic Research Society
    • Place of Presentation
      San Antonio, TX, USA.
    • Year and Date
      20130126-29
  • [Presentation] Design of Powered Orthosis Based on 3D Neuro-musculo-skeletal Human Model (invited)2012

    • Author(s)
      G. Obinata, C. Nagai, Y. Kim, Y. Uchiyama, K. Hase
    • Organizer
      The 10th IFAC Symposium on Robot Control (SYROCO'12)
    • Place of Presentation
      Dubrovnik, Croatia
    • Year and Date
      20120905-07
  • [Presentation] Motoneuron integrated striated muscle(MISM) による麻痺筋の機能再構築2012

    • Author(s)
      平田仁
    • Organizer
      日本末梢神経学会(シンポジウム)
    • Place of Presentation
      北九州市(九州大学医学部百年講堂)
    • Year and Date
      20120831-0901
  • [Presentation] Percutaneous electrical stimulation to motoneuron integrated striated muscles2012

    • Author(s)
      Kato S, Kurimot S, Hirata H, et al
    • Organizer
      Orthopaedic Research Society.
    • Place of Presentation
      San Francisco, CA, USA.
    • Year and Date
      20120204-07
  • [Presentation] Motoneuron integraed striated muscle(MISM)による局所制御システムの開発2012

    • Author(s)
      栗本秀, 平田仁 他
    • Organizer
      マイクロナノメカトロニクスGCOEシンポジウム(招待講演)
    • Place of Presentation
      名古屋市(名古屋大学医系研究棟1号館地下会議室)
    • Year and Date
      2012-03-08
  • [Presentation] Transplantation of embryonic neurons into peripheral nerve forms functional motor units2011

    • Author(s)
      Kurimot S, Hirata H, Kato S, et al
    • Organizer
      Orthopaedic Research Society
    • Place of Presentation
      Long Beach CA, USA.
    • Year and Date
      20110113-16
  • [Book] 人工神経.「人工臓器は、いま」日本人工臓器学会編2012

    • Author(s)
      平田仁
    • Total Pages
      379-394
    • Publisher
      はる書房

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Published: 2014-08-29   Modified: 2015-01-06  

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