Multiple analyses of epigenetics modification under neuropathic pain

2013 Fiscal Year Final Research Report

• Project/Area Number: 22390300
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Hoshi University
• Principal Investigator: NARITA Minoru 星薬科大学, 薬学部, 教授 (40318613)
• Project Period (FY): 2010-04-01 – 2014-03-31
• Keywords: エピジェネティクス / 慢性疼痛 / 脊髄 / ヒストン修飾

Research Abstract

Clinically, it is well-known that chronic pain induces depression, anxiety, and reduced quality of life. Neuropathic pain, which is characterized by spontaneous burning pain, hyperalgesia and allodynia is the most difficult pain to manage in the pain clinic. However, the complicated pathophysiology of the neuropathic pain is not yet understood. A better understanding of its pathophysiology has given us more insight into its various mechanisms and possible treatment options. In this study, chronic pain-induced epigenetic changes in cellar function was focused to explain the pain-induced synaptic plasticity and cell memory. For global understanding of the pain, it is necessary to analyze the correlation between these temporal parameters and phenomics.

Research Products

• [Journal Article] Astrocytic activation in the anterior cingulate cortex is critical for sleep disorder under neuropathic pain (2014)
  • Author(s): Yamashita A, Hamada A, Suhara Y, Kawabe R, Yanase M, Kuzumaki N, Narita M, Matsui R, Okano H, Narita M
  • Journal Title: Synapse Volume: 68 Pages: 235-47
• [Journal Article] Changes in circadian rhythm for mRNA expression of melatonin 1A and 1B receptors in the hypothalamus under a neuropathic pain-like state (2014)
  • Author(s): Odo M, Koh K, Takada T, Yamashita A, Narita M, Kuzumaki N, Ikegami D, Sakai H, Iseki M, Inada E, Narita M
  • Journal Title: Synapse Volume: 68 Pages: 253-8
• [Journal Article] Analysis of sleep disorders under pain using an optogenetic tool : possible involvement of the activation of dorsal raphe nucleus-serotonergic neurons (2013)
  • Author(s): Ito H, Yanase M, Yamashita A, Kitabatake C, Hamada A, Suhara Y, Narita M, Ikegami D, Sakai H, Yamazaki M, Narita M
  • Journal Title: Mol Brain Volume: 6 Pages: 59
• [Journal Article] Epigenetic transcriptional activation of monocyte chemotactic protein 3 contributes to long-lasting neuropathic pain (2013)
  • Author(s): Imai S, Ikegami D, Yamashita A, Shimizu T, Narita M, Niikura K, Furuya M, Kobayashi Y, Miyashita K, Okutsu D, Kato A, Nakamura A, Araki A, Omi K, Nakamura M, James Okano H, Okano H, Ando T, Takeshima H, Ushijima T, Kuzumaki N, Suzuki T, Narita M
  • Journal Title: Brain Volume: 136 Pages: 828-43
• [Journal Article] Changes in the circadian rhythm of mRNA expression for μ-opioid receptors in the periaqueductal gray under a neuropathic pain-like state (2013)
  • Author(s): Takada T, Yamashita A, Date A, Yanase M, Suhara Y, Hamada A, Sakai H, Ikegami D, Iseki M, Inada E, Narita M
  • Journal Title: Synapse Volume: 67 Pages: 216-23
• [Journal Article] Usefulness of olanzapine as an adjunct to opioid treatment and for the treatment of neuropathic pain (2012)
  • Author(s): Torigoe K, Nakahara K, Rahmadi M, Yoshizawa K, Horiuchi H, Hirayama S, Imai S, Kuzumaki N, Itoh T, Yamashita A, Shakunaga K, Yamasaki M, Nagase H, Matoba M, Suzuki T, Narita M
  • Journal Title: Anesthesiology Volume: 116 Pages: 159-69
• [Journal Article] Effects of mirtazapine on sleep disturbance under neuropathic pain-like state (2012)
  • Author(s): Enomoto T, Yamashita A, Torigoe K, Horiuchi H, Hirayama S, Nakahara K, Yanase M, Sakai H, Ikegami D, Nagase H, Suzuki T, Iseki M, Inada E, Narita M
  • Journal Title: Synapse Volume: 66 Pages: 483-8
• [Journal Article] Change in microRNAs associated with neuronal adaptive responses in the nucleus accumbens under neuropathic pain (2011)
  • Author(s): Imai S, Saeki M, Yanase M, Horiuchi H, Abe M, Narita M, Kuzumaki N, Suzuki T, and Narita M
  • Journal Title: Journal of Neuroscience Volume: 31 Pages: 15294-15299
• [Journal Article] Sleep disturbances in a neuropathic pain-like condition in the mouse are associated with altered GABAergic transmission in the cingulate cortex (2011)
  • Author(s): Narita M, Niikura K, Nanjo-Niikura K, Narita M, Furuya M, Yamashita A, Saeki M, Matsushima Y, Imai S, Shimizu T, Asato M, Kuzumaki N, Okutsu D, Miyoshi K, Suzuki M, Tsukiyama Y, Konno M, Yomiya K, Matoba M and Suzuki T
  • Journal Title: Pain Volume: 152 Pages: 1358-72
• [Journal Article] Direct evidence for the ongoing brain activation by enhanced dynorphinergic system in the spinal cord under inflammatory noxious stimuli (2010)
  • Author(s): Taketa Y, Niikura K, Kobayashi Y, Furuya M, Shimizu T, Narita M, Imai S, Kuzumaki N, Maitani Y, Yamazaki M, Inada E, Iseki M, Suzuki T and Narita M
  • Journal Title: Anesthesiolosy Volume: 112 Pages: 418-431
• [Presentation] Choronic Nociceptive stimuli negativery control the mesolimbic dopaminergic transmission (2013)
  • Author(s): Narita, M., Yamashita, A
  • Organizer: International Narcotics Research Conference(INRC) Annual Meeting 2013
  • Place of Presentation: Cairns, Australia
  • Year and Date: 20130714-19
  • Invited
• [Presentation] "痛みの記憶"と"痛みストレス"の統合的理解 (2012)
  • Author(s): 成田年
  • Organizer: 第5回宮城県痛みを考える会
  • Place of Presentation: 仙台
  • Year and Date: 2012-06-30
• [Presentation] 痛みの多次元解析 : "痛み記憶"の解釈 (2012)
  • Author(s): 成田年
  • Organizer: 第3回福島県痛みを考える会
  • Place of Presentation: 福島
  • Year and Date: 2012-05-12
• [Book] 分子病態薬理学II痛みの病態と治療,そして緩和医療 (2013)
  • Author(s): 成田年, 酒井寛泰, 池上大悟
  • Publisher: 京都廣川書店