2012 Fiscal Year Final Research Report
Comprehensive genome analysis for prostate cancer biomarkers
| Project/Area Number |
22390306
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
NAKAGAWA Hidewaki 独立行政法人理化学研究所, バイオマーカー探索開発チーム, チームリーダー (50361621)
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| Co-Investigator(Renkei-kenkyūsha) |
KUBO Michiaki 独立行政法人理化学研究所, ゲノム医科学研究センター, 副センター長 (30442958)
FURIHATA Mutsuo 高知大学, 医学部, 教授 (10209158)
TAKATA Ryo 岩手医科大学, 医学部, 助教 (00438467)
OGAWA Osamu 京都大学, 医学部, 教授 (90260611)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 前立腺癌 / ゲノム / GWAS / SNP |
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| Research Abstract |
We performed follow-up Japanese GWAS (genome-wide association study) on additional Japanese DNA samples, and identified novel 4 loci associated with prostate cancer. The functional analysis of IRX4 and GGCX, which were identified by our GWAS, indicated novel mechanism of prostate carcinogenesis. We established a risk prediction model for Japanese prostate cancer and validated its consistency and accuracy.
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